0000000000511305

AUTHOR

Udo Schumacher

showing 4 related works from this author

Coptis chinensis Franch. exhibits neuroprotective properties against oxidative stress in human neuroblastoma cells.

2014

Abstract Ethnopharmacological relevance The dried rhizome of Coptis chinensis Franch. (family Ranunculaceae ) is traditionally used in Chinese medicine for the treatment of inflammatory diseases and diabetes. Recent studies showed a variety of activities of Coptis chinensis Franch. alkaloids, including neuroprotective, neuroregenerative, anti-diabetic, anti-oxidative and anti-inflammatory effects. However, there is no report on the neuroprotective effect of Coptis chinensis Franch. watery extract against tert -butylhydroperoxide ( t -BOOH) induced oxidative damage. The aim of the study is to investigate neuroprotective properties of Coptis chinensis Franch. rhizome watery extract (CRE) and …

SH-SY5YTime FactorsCell SurvivalApoptosisPharmacologymedicine.disease_causeNeuroprotectionNeuroblastomatert-ButylhydroperoxideCell Line TumorDrug DiscoveryMedicineHumansViability assayPharmacologychemistry.chemical_classificationMembrane Potential MitochondrialReactive oxygen speciesbiologyTraditional medicinebusiness.industryPlant ExtractsReverse Transcriptase Polymerase Chain ReactionCoptis chinensisbiology.organism_classificationMicroarray AnalysisOxidative StressNeuroprotective AgentschemistryApoptosisbusinessReactive Oxygen SpeciesTXNIPOxidative stressRhizomeCoptisJournal of ethnopharmacology
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Pharmacogenomics of cantharidin in tumor cells.

2014

Cantharis vesicatoria (blister beetle) is used in Chinese medicine and has been categorized as highly toxic in the Chinese pharmacopeia. In Europe, Cantharis patches have been used since ages to treat various skin-related diseases. We investigated the cytotoxicity of the Cantharis ingredient, cantharidin, in 41 tumor cell lines (Oncotest panel) and compared the results with those of 60 cell lines of the National Cancer Institute, USA. We found profound activity at low micromolar concentrations (log ₁₀IC₅₀ values between -6.980 and 5.009 M). Cantharidin bound to protein phosphatase 2A (PP2A) with higher affinity (-8.12 kcal/mol) than to PP1 (-6.25 kcal/mol) in molecular docking analyses. Usi…

Models MolecularProtein ConformationBlister beetleBiologyCantharisBiochemistryFas ligandGene Expression Regulation Enzymologicchemistry.chemical_compoundCell Line TumorGene expressionAnimalsHumansRNA MessengerCytotoxicityOligonucleotide Array Sequence AnalysisPharmacologyCantharidinBinding SitesMolecular Structurebiology.organism_classificationMolecular biologyReceptors Neuropeptide YchemistryCell cultureApoptosisPharmacogeneticsImmunologyCantharidinBiochemical pharmacology
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Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies

2017

Background: During the last decades, a huge body of evidence has been accumulated suggesting that Citrus fruits and their juices might have a role in preventing many diseases including cancer. Objective: To summarize the numerous evidences on the potential of Citrus juices and their extracts as anticancer agents. Data sources: A systematic review of articles written in English using MEDLINE (1946-present), EMBASE (1974-present) and Web of Sciences (1970-present) was performed independently by two reviewers. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, cancer, neoplasm, neoplasia, tumor, metastasis, carcinogenesis,…

0301 basic medicineproliferationCitrus aurantifoliaUremic toxinsMEDLINECITRUS JUICEIndoxyl sulfate03 medical and health sciences0302 clinical medicineNeuroinflammationsystematic reviewCitrus paradisiChronic kidney diseaseBotanycancerMedicinePharmacology (medical)NeurodegenerationSystematic reviehumansPharmacologyTraditional medicineIndoxyl sulfate Neuroinflammation Oxidative stress Neurodegeneration Uremic toxins Chronic kidney disease Alternative medicine Cancer Citrus juice Humans In vitro In vivo Proliferation Systematic revie Pharmacology Pharmacology (medical)alternative medicinebusiness.industryData synthesislcsh:RM1-950food and beveragesin vitroin vivolcsh:Therapeutics. Pharmacology030104 developmental biologySystematic reviewSearch termsOxidative stress030220 oncology & carcinogenesisCitrus juicebusinessCitrus × sinensisFrontiers in Pharmacology
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Influence of nifedipine on the metabolism of gingival fibroblasts.

1994

Calcium antagonists are the gold standard in the therapy of coronary heart disease and hypertension. The prototype of these drugs is nifedipine which, as well as its therapeutic effects on the cells of the cardiovascular system, also has unpleasant side effects on other organ systems. One side effect can be a missive hyperplasia of the gingiva, the reason for which are unclear. In vitro experiments were designed to elucidate the influence of nifedipine on the growth of human gingival fibroblasts in short and long term (72 hours, 6 weeks) cell culture. The following cellular parameters were determined quantitatively: cell proliferation (cell count, [3H]thymidine incorporation), protein synth…

AdultSide effectNifedipineCell SurvivalCellGingivaPharmacologyBiochemistrychemistry.chemical_compoundNifedipineCyclosporin aLactate dehydrogenasemedicineHumansCells CulturedDose-Response Relationship DrugChemistryCell growthDNAHyperplasiaFibroblastsmedicine.diseaseChromatography Ion Exchangemedicine.anatomical_structureCell cultureProtein BiosynthesisProteoglycansCell Divisionmedicine.drugBiological chemistry Hoppe-Seyler
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