0000000000512989

AUTHOR

Magí Farré

showing 5 related works from this author

Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

2018

Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without ty…

0301 basic medicineGerontologyBlood GlucoseMaleLentilsMediterranean dietPREDIMED-study030209 endocrinology & metabolismContext (language use)Type 2 diabetesCritical Care and Intensive Care MedicineLower riskDiet Mediterranean03 medical and health sciences0302 clinical medicineRisk FactorsDiabetes mellitusmedicineHumansProspective StudiesGlycemicAdiposityAgedProportional Hazards Models030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industryFabaceaeType 2 diabetesMiddle Agedmedicine.diseaseLegumesDietGlycemic indexQuartileDiabetes Mellitus Type 2Glycemic IndexFemalebusinessDemographyFollow-Up Studies
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Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats

2013

Hydroxytyrosol (HT), one of the major polyphenols present in olive oil, is known to possess a high antioxidant capacity. The aim of the present study was to investigate dose dependent (0, 1, 10 and 100 mg/kg) alterations in the metabolism of HT in rats since it has been reported that metabolites may contribute to biological effects. Special attention was paid to the activation of the semiquinone quinone oxidative cycle and the formation of adducts with potential deleterious effects. Thus, we developed a novel analytical methodology to monitor the in vivo formation of the HT mercapturate, N-acetyl-5-S-cysteinyl-hydroxytyrosol in urine samples. Biomarkers of hepatic and renal toxicity were ev…

MaleMercapturate adductsPharmacologyGlucuronidation PathwayAntioxidantschemistry.chemical_compoundSulfationIn vivoHomovanillyl alcoholAnimalsPharmacologyGlutathione Oxidative damageHydroxytyrosol metabolismDose-Response Relationship DrugGlutathione DisulfidePolyphenolsGlutathioneMetabolismPhenylethyl AlcoholGlutathioneAcetylcysteineRatsBiochemistrychemistryToxicityHydroxytyrosolFemale
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Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

2019

[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts.

AdultMale0301 basic medicinemedicine.medical_specialtyMediterranean diet030209 endocrinology & metabolismContext (language use)Type 2 diabetesDiet MediterraneanCritical Care and Intensive Care MedicineDietary inflammatory indexBody Mass IndexYoung Adult03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineMediterranean dietHumansMedicineObesityProspective StudiesMortalityProspective cohort studyRandomized Controlled Trials as TopicInflammation030109 nutrition & dieteticsNutrition and Dieteticsbusiness.industrySmokingHazard ratioMiddle Agedmedicine.diseaseObesityDietC-Reactive ProteinDiabetes Mellitus Type 2CohortPatient ComplianceCohort studiesFemalebusinessCRPCohort study
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Neuroimagen y adicción I: Correlatos neuroanatómicos y funcionales de la administración aguda, el craving y el consumo crónico de psicoestimulantes

2007

En los últimos años ha aumentado el interés por el estudio de los correlatos neurobiológicos del consumo de drogas psicoestimulantes, como la cocaína o el éxtasis. La aplicación de las técnicas de neuroimagen ha permitido examinar in vivo los efectos agudos de la administración de estas sustancias, los correlatos cerebrales del deseo intenso por consumirlas (craving), o las alteraciones funcionales o morfológicas asociadas al consumo crónico. Los objetivos de esta revisión son: (1) explicar brevemente las técnicas de neuroimagen utilizadas en la investigación de drogodependencias (2) presentar los hallazgos más actualizados de neuroimagen en el estudio de los correlatos cerebrales del consu…

:PSICOLOGÍA::Psicofarmacología [UNESCO]:PSICOLOGÍA [UNESCO]Neuroimagen adicción cocaína éxtasis administración craving consumo crónicoUNESCO::PSICOLOGÍAUNESCO::PSICOLOGÍA::Psicofarmacología
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Neuroimagen y adicción II: Correlatos neuroanatómicos y funcionales de la administración aguda, el craving y el consumo crónico de opiáceos, alcohol …

2008

En las últimas décadas las técnicas de neuroimagen han contribuido en gran medida al estudio in vivo de los efectos neurobiológicos del consumo agudo y crónico de sustancias de abuso. El incremento en los últimos años del consumo de alcohol y cannabis, así como las graves consecuencias asociadas al consumo de opiáceos han contribuido al aumento del interés por estudiar los efectos de estas sustancias en el sistema nervioso central. Los objetivos de esta revisión son: (1) presentar los hallazgos más actualizados de neuroimagen en el estudio de los correlatos cerebrales del consumo de opiáceos, alcohol y cannabis, teniendo en cuenta: (i) la administración aguda de estas sustancias, (ii) el cr…

:PSICOLOGÍA::Psicofarmacología [UNESCO]Neuroimagen adicción alcohol heroína cannabis administración aguda craving consumo crónico.:PSICOLOGÍA [UNESCO]UNESCO::PSICOLOGÍAUNESCO::PSICOLOGÍA::Psicofarmacología
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