Author: Andreas C. M. Gunell

0000000000513170

AUTHOR

Andreas C. M. Gunell

Improved synthesis and application of conjugation-amenable polyols from d-mannose

A series of polyhydroxyl sulfides and triazoles was prepared by reacting allyl and propargyl D-mannose derivatives with selected thiols and azides in thiol–ene and Huisgen click reactions. Conformational analysis by NMR spectroscopy proved that the intrinsic rigidity and linear conformation of the mannose derived polyol backbone is retained in the final click products in solution. Single crystal X-ray structure determination of one of the compounds prepared further verified that the linear conformation of the polyol segment is also retained in the solid state. In addition, an improved method for direct Barbier-type propargylation of unprotected D-mannose is reported. The new reaction protoc…

research product

CCDC 1956436: Experimental Crystal Structure Determination

Related Article: Ida Mattsson, Ruzal Sitdikov, Andreas C. M. Gunell, Manu Lahtinen, Tiina Saloranta-Simell, Reko Leino|2020|RSC Advances|10|3960|doi:10.1039/C9RA10378C

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PEPhysical Sciences and Engineering
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LSLife Sciences
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