Current and/ or life time use of cannabis as a factor of vulnerability in psychotic disorders

Gene X cannabis interaction: Case-only design analysis in a first-episode psychosis sample

Educational achievement, cannabis use, and genotype in predicting psychosis

COGNITION, METACOGNITION AND SOCIAL COGNITION AFTER A FIRST EPISODE PSYCHOSIS. PRELIMINARY RESULTS FROM A 5-YEAR-FOLLOW-UP STUDY

Is cerebral asymmetry associated with serotonin transporter in psychosis?

First-Episode Psychosis Patients Who Deteriorated in the Premorbid Period Do Not Have Higher Polygenic Risk Scores Than Others: A Cluster Analysis of EU-GEI Data

Abstract Cluster studies identified a subgroup of patients with psychosis whose premorbid adjustment deteriorates before the onset, which may reflect variation in genetic influence. However, other studies reported a complex relationship between distinctive patterns of cannabis use and cognitive and premorbid impairment that is worthy of consideration. We examined whether: (1) premorbid social functioning (PSF) and premorbid academic functioning (PAF) in childhood and adolescence and current intellectual quotient (IQ) define different clusters in 802 first-episode of psychosis (FEP) patients; resulting clusters vary in (2) polygenic risk scores (PRSs) for schizophrenia (SCZ_PRS), bipolar dis…

PREVALENCE OF BULLYING AMONGST FIRST-EPISODE PSYCHOSIS PATIENTS AND UNAFFECTED CONTROLS

Background:Despite increasing evidence suggesting that childhood mal-treatment is significantly associated with psychotic disorders, the role ofbullying in the later development of psychosis is still controversial (Kelle-her et al., 2008, Arseneault et al., 2011). Therefore, this study examinedthe prevalence of bullying amongst first-episode psychosis patients andunaffected controlsMethods:Data were collected from 227 first-presentation psychosis casesand 215 geographically-matched controls. Bullying was assessed as partof the Brief Life Events schedule. Patients and controls were shown acard listing 10 adverse events, including “bullying”, “sexual abuse”, “beingexpelled from school”, and a…

A first episode psychosis case-control genetic association study

Background:GAP(genesandpsychosis) is a case-control studyof first episode psychosis conducted in London and Cambridge, which aims to identify genes conferring susceptibility to psychosis, and associated phenotypes including cognitive dysfunction and cerebral morphology. Methods:First episode psychosis cases have been recruited in South London and Maudsley NHS Trust and in Cambridge. A variety of demographic and clinical data have been collected. In a subset of these, neurocognitive assessments and MRIs have been performed. Samples have been taken for DNA, and in a subset for RNA and proteomic analysis. Genetic association analysis is being undertaken using a candidate gene approach. The gen…

Differences between female and male gamers and gender-specific risk-factors for internet gaming disorder (IGD)

Introduction: Videogames have become more popular across females, although their widespread diffusion among males. How- ever, few studies have examined differences between female and male gamers and gender-specific risk factors for Internet Gaming Disorder (IGD). Objectives: The study aimed to describe males and females’ differ- ences in a sample of gamers, and to identify gender-specific risk- factors for IGD, accounting for alexithymia, playing habits, and other perceived stressors. Methods: Participants were gamers joining online communities, tested by IGDS-SF9 and TAS-20 for alexithymia. To explore isk-factors for IGD (outcome: IGD>=21), we set a binary logistic regression stratified…

Daily use of high-potency cannabis is associated with more positive symptoms in first-episode psychosis patients: The EU-GEI case-control study

The work was supported by: Clinician Scientist Medical Research Council fellowship (project reference MR/M008436/1) to MDF; the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital NHS Foundation Trust to DQ; DFG Heisenberg professorship (no. 389624707) to UR. National Institute for Health Research (NIHR) Biomedical Research Centre for Mental Health at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The EU-GEI Project is funded by t…

The role of different game-genres in predicting internet gaming disorder (IGD)

Introduction: Internet gaming disorder (IGD) is a new diagnosis in DSM 5 worth of research. New potentially addictive features are emerging in pay- and free-to-play videogames, involving different at-risk populations of gamers. However, few studies have examined whether and how different game-genres can contribute to the risk of IGD. Objectives: This study aimed to investigate how game-genres can predict IGD, accounting for alexithymia scores, time-related play- ing habits, and other predictors. Methods: Participants were gamers joining online communities, surveyed about which games they played more than 20 hours in their lifetime, time-variables, other stressors and alexithymia scores. A s…

NUOVE DIPENDENZE. ETIOLOGIA, CLINICA E TRATTAMENTO DELLE DIPENDENZE "SENZA DROGA". VOLUME MONOGRAFICO RIVISTA NOOS

IL VOLUME RACCOGLIE ARTICOLI RELATIVI AL TEMA DELLE DIPENDENZE SENZA DROGHE, CON PARTICOLARE RIFERIMENTO AL GIOCO D'AZZARDO, ALL'INTERNET ADDICTION, ALLO SHOPPING COMPULSIVO. TALI DISTURBI VENGONO AFFRONTATI DAL PUNTO DI VISTA ETIOLOGICO, DIAGNOSTICO E TERAPEUTICO.