0000000000514319
AUTHOR
P. Crivelli
Real-life impact of early interferon beta therapy in relapsing multiple sclerosis.
OBJECTIVE: Recent findings support greater efficacy of early vs. delayed interferon beta (IFNbeta) treatment in patients with a first clinical event suggestive of multiple sclerosis (MS). We aimed to evaluate the effectiveness of early IFNbeta treatment in definite relapsing-remitting MS (RRMS) and to assess the optimal time to initiate IFNbeta treatment with regard to the greatest benefits on disability progression. METHODS: A cohort of 2,570 IFNbeta-treated RRMS patients was prospectively followed for up to 7 years in 15 Italian MS Centers. A Cox proportional hazards regression model adjusted for propensity score (PS) quintiles was used to assess differences between groups of patients wit…
Towards a test of the weak equivalence principle of gravity using anti-hydrogen at CERN
International audience; The aim of the GBAR (Gravitational Behavior of Antimatter at Rest) experiment is to measure the free fall acceleration of an antihydrogen atom, in the terrestrial gravitational field at CERN and therefore test the Weak Equivalence Principle with antimatter. The aim is to measure the local gravity with a 1% uncertainty which can be reduced to few parts of 10-3.
LBNO-DEMO: Large-scale neutrino detector demonstrators for phased performance assessment in view of a long-baseline oscillation experiment
In June 2012, an Expression of Interest for a long-baseline experiment (LBNO) has been submitted to the CERN SPSC. LBNO considers three types of neutrino detector technologies: a double-phase liquid argon (LAr) TPC and a magnetised iron detector as far detectors. For the near detector, a high-pressure gas TPC embedded in a calorimeter and a magnet is the baseline design. A mandatory milestone is a concrete prototyping effort towards the envisioned large-scale detectors, and an accompanying campaign of measurements aimed at assessing the detector associated systematic errors. The proposed $6\times 6\times 6$m$^3$ DLAr is an industrial prototype of the design discussed in the EoI and scalable…