0000000000514923

AUTHOR

A. Pace

showing 27 related works from this author

Efficacy, safety and tolerability of combined low-dose simvastatin-fenofibrate treatment in primary mixed hyperlipidaemia.

2007

In order to assess the long-term (12 months) efficacy and safety of fenofibrate administered with simvastatin in the treatment of primary mixed hyperlipidaemia, we conducted a study that compared increasing dosages of these drugs in subgroups of men and women belonging to a clinical sample of outpatients. This was an open study carried out in patients with primary mixed hyperlipidaemia (lipoprotein phenotype IIb) who needed a combined therapeutic approach because of their poor response to a single-drug regimen with an HMG-CoA reductase inhibitor (simvastatin). Thus, a fibrate (fenofibrate) was added to the therapy. The study lasted 12 months. Forty-five patients (mean age: 58.9 ± 11.3 years…

medicine.medical_specialtyFenofibrateDosemedicine.drug_classbusiness.industrynutritional and metabolic diseasesGeneral MedicineFibratePharmacologyGastroenterologyDiscontinuationRegimenTolerabilitySimvastatinInternal medicinemedicinelipids (amino acids peptides and proteins)Pharmacology (medical)Adverse effectbusinessmedicine.drugClinical drug investigation
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Thin-Film Heterojunction by Carbon Nanotube Derivatives with Enhanced Solubility and Optical Properties

2012

Carbon nanotubes Bulk heterojunctions Organic solar cells Photovoltaics
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Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models

nonsense mutationSettore CHIM/06 - Chimica OrganicaTRIDReadthrough
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Tutor-Sky: A web environment for multimedia on-line education

2005

Computer Science and Telecommunication technologies are being more and more integrated in teaching and learning systems. The subsequent modification of the educational world becomes a natural event towards a student who is immersed in a multimedia technological society and expects to find a similar learning environment. At present, multimedia is widely used in education to improve and integrate the learning processes and is ever more used in on-line education where the different media help in re-creating the “natural” interaction between teachers and students. There are many tools that allow creation and publication on web of learning contents, but none of them allows teachers to easily and…

Multimedia web environment On line Education E-learning
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Synthesis of Fluorinated Bent-Core Mesogens (BCMs) Containing the 1,2,4-Oxadiazole Ring

2015

New fluorinated bent-core mesogens containing the 1,2,4-oxadiazole or 1,2,4-triazole nucleus have been synthesized taking advantage of the ANRORC (Addition of Nucleophile, Ring-Opening, Ring-Closure) reactivity of 5-perfluoroalkyl-1,2,4-oxadiazoles. Physical state changes of the obtained compounds were characterized through DSC, POM, and SAXS. Besides the formation of a smectic mesophase, a novel behavior as organic molecular glass was evidenced for some 1,2,4-oxadiazole derivatives.

Oxadiazole Fluorinated materials triazole Liquid crystalsSettore CHIM/06 - Chimica Organica
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Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codon…

2015

cystic fibrosiscomputational approaches; readthrough; premature stop codon; cystic fibrosisreadthroughpremature stop codoncomputational approache
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Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells

2016

readthrough; premature stop codons; PTC; cystic fibrosis; novel moleculesnovel moleculesPTCreadthroughpremature stop codoncystic fibrosi
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Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells

2017

Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells Laura Lentini, Raffaella Melfi, Sara Baldassano, Marco Tutone, Aldo Di Leonardo, Andrea Pace, Ivana Pibiri Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo Background and rationale Cystic Fibrosis patients with nonsense mutations in the CFTR gene have a more severe form of the disease. Nonsense mutations represent about 10% of the mutations that affect the CFTR gene and they are frequently associated to the classical F508 mutation (1). A potential treatment for this genetic alteration is to promote the translationa…

Settore BIO/18 - Genetica-Fluorinated heterocycles -Nonsense Mutations -Premature stop codon -ReadthroughSettore BIO/11 - Biologia MolecolareSettore CHIM/06 - Chimica OrganicaSettore BIO/09 - FisiologiaSettore CHIM/08 - Chimica Farmaceutica
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A NEW WATER-SOLUBLE FLUORINATED POLYMER BASED ON A POLYASPARTAMIDE AND OXADIAZOLE UNITS AS A POTENTIAL ARTIFICIAL OXYGEN (O2) CARRIER

2006

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CCDC 633320: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(Z)-N-((2233-tetramethylaziridin-1-yl)(phenyl)methylene)benzamideExperimental 3D Coordinates
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CCDC 621722: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, S.Pappalardo, D.Garozzo, T.Pilati, G.Gattuso, A.Pappalardo, I.Pisagatti, M.F.Parisi|2006|Tetrahedron Lett.|47|9049|doi:10.1016/j.tetlet.2006.10.092

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates511172329-Penta-t-butyl-3132333435-pentakis(4-(3-pentadecafluoroheptyl-124-oxadiazol-5-yl)tetrafluorophenyl)calix(5)arene
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CCDC 633321: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, I.Pibiri, A.Pace, R.A.Raccuglia, S.Buscemi, N.Vivona, G.Giorgi|2007|Heterocycles|71|1529|doi:10.3987/COM-07-11040

Space GroupCrystallographyCrystal System(Z)-N-((23-dimethylbut-3-en-2-ylamino)(phenyl)methylene)benzamideCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 271045: Experimental Crystal Structure Determination

2005

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, G.Macaluso, N.Vivona, D.Spinelli, G.Giorgi|2005|J.Org.Chem.|70|3288|doi:10.1021/jo047766s

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-Trifluoromethyl-6-phenyl-2H-124-triazin-5-one Z-oxime p-bromobenzoateExperimental 3D Coordinates
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CCDC 804195: Experimental Crystal Structure Determination

2011

Related Article: A.Terenzi, G.Barone, A.P.Piccionello, G.Giorgi, A.Guarcello, A.Pace|2011|Inorg.Chim.Acta|373|62|doi:10.1016/j.ica.2011.03.057

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersbis(perchlorato)-bis(2-(5-phenyl-124-oxadiazol-3-yl)pyridine)-copper(ii)Experimental 3D Coordinates
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CCDC 630243: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters3-(Pentadecafluoroheptyl)-1-methyl-5-phenyl-1H-(124)-triazoleExperimental 3D Coordinates
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CCDC 915396: Experimental Crystal Structure Determination

2013

Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A

Space GroupCrystallography11223344-Octafluoro-14-diiodobutane 44'-(124-oxadiazole-35-diyl)dipyridineCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 630242: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureCell ParametersN^1^-Methyl-5-hydroxylimino-3-pentadecafluoroheptyl-124-triazin-6-one ethanol solvateExperimental 3D Coordinates
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CCDC 653860: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, A.Pace, S.Buscemi, N.Vivona, M.Pani|2008|Tetrahedron|64|4004|doi:10.1016/j.tet.2008.02.047

2-amino-4-trifluoromethyl-5-benzoyl-1H-imidazoleSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 245638: Experimental Crystal Structure Determination

2004

Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e

Space GroupCrystallography1-Methyl-3-N-methylamino-5-pentadecafluoroheptyl-124-triazoleCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 279694: Experimental Crystal Structure Determination

2006

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, N.Vivona, M.Pani|2006|Tetrahedron|62|1158|doi:10.1016/j.tet.2005.10.071

Space GroupCrystallographyCrystal SystemCrystal Structure2-Amino-6-methyl-4-(trifluoromethyl)-pyrimidine-1-oxideCell ParametersExperimental 3D Coordinates
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CCDC 279693: Experimental Crystal Structure Determination

2006

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, N.Vivona, M.Pani|2006|Tetrahedron|62|1158|doi:10.1016/j.tet.2005.10.071

Space GroupCrystallographyCrystal System2-Amino-4-methyl-6-(trifluoromethyl)-pyrimidine-1-oxideCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 749593: Experimental Crystal Structure Determination

2011

Related Article: A.Terenzi, G.Barone, A.P.Piccionello, G.Giorgi, A.Guarcello, P.Portanova, G.Calvaruso, S.Buscemi, N.Vivona, A.Pace|2010|Dalton Trans.|39|9140|doi:10.1039/c0dt00266f

Space GroupCrystallographybis(35-bis(2-pyridyl)-124-oxadiazole)-diaqua-copper(ii) diperchlorateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 245639: Experimental Crystal Structure Determination

2004

Related Article: A.Pace, I.Pibiri, S.Buscemi, N.Vivona, L.Malpezzi|2004|J.Org.Chem.|69|4108|doi:10.1021/jo049814e

Space GroupCrystallographyCrystal System2-N-Methylamino-5-trifluoromethyl-134-oxadiazoleCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 653859: Experimental Crystal Structure Determination

2008

Related Article: A.P.Piccionello, A.Pace, S.Buscemi, N.Vivona, M.Pani|2008|Tetrahedron|64|4004|doi:10.1016/j.tet.2008.02.047

Space GroupCrystallographyCrystal System111-trifluoro-N-(5-phenyl-124-oxadiazol-3-yl)-4-amino-pent-3-en-2-oneCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 915397: Experimental Crystal Structure Determination

2013

Related Article: M.Saccone,G.Cavallo,P.Metrangolo,A.Pace,I.Pibiri,T.Pilati,G.Resnati,G.Terraneo|2013|CrystEngComm|15|3102|doi:10.1039/C3CE40268A

112233445566-Dodecafluoro-16-diiodohexane 44'-(124-oxadiazole-35-diyl)dipyridineSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 635325: Experimental Crystal Structure Determination

2010

Related Article: A.Mugnoli, G.Barone, S.Buscemi, C.Z.Lanza, A.Pace, M.Pani, D.Spinelli|2009|J.Phys.Org.Chem.|22|1086|doi:10.1002/poc.1563

Space GroupCrystallographyCrystal SystemN-(5-Methyl-124-oxadiazol-3-yl)acetamideCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 630241: Experimental Crystal Structure Determination

2007

Related Article: S.Buscemi, A.Pace, A.P.Piccionello, I.Pibiri, N.Vivona, G.Giorgi, A.Mazzanti, D.Spinelli|2006|J.Org.Chem.|71|8106|doi:10.1021/jo061251e

Space GroupCrystallographyCrystal SystemCrystal StructureNO-Dibenzoyl-5-hydroxylamino-3-heptafluoropropyl-124-triazin-6-oneCell ParametersExperimental 3D Coordinates
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