0000000000516050

AUTHOR

Enrique Viturro

showing 1 related works from this author

Cholesterol and saturated fat intake determine the effect of polymorphisms at ABCG5/ABCG8 genes on lipid levels in children.

2006

Purpose: Analysis of mutations in genes of the cholesterol metabolic pathway has not completely explained the interindividual variability of blood cholesterol concentrations attributed to gene–nutrient interactions. Thus, we analyzed polymorphisms in the ABCG5 and ABCG8 genes, involved in the regulation of intestinal cholesterol absorption, with special interest in a potential interaction with diet to determine lipid levels. Methods: The polymorphisms ABCG5 C1950G (Gln604Glu) and ABCG8 C1895T (Ala640Val) were determined by polymerase chain reaction and restriction analysis in 1227 healthy school children, aged 6 to 8 years. Results: No significant differences were found in blood lipid level…

Malemedicine.medical_specialtyApolipoprotein BLipoproteinsBlood lipidsABCG8Cholesterol Dietarychemistry.chemical_compoundGene FrequencyPolymorphism (computer science)Internal medicineSurveys and QuestionnairesGenotypemedicineHumansATP Binding Cassette Transporter Subfamily G Member 5ChildGenetics (clinical)GeneticsPolymorphism GeneticbiologyBase SequenceCholesterolATP Binding Cassette Transporter Subfamily G Member 8DNADietary FatsLipidsEndocrinologychemistryABCG5biology.proteinIntestinal cholesterol absorptionlipids (amino acids peptides and proteins)ATP-Binding Cassette TransportersFemaleGenetics in medicine : official journal of the American College of Medical Genetics
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