0000000000519598

AUTHOR

Stroffolini Tommaso

showing 3 related works from this author

Endemic hepatitis C virus infection in a Sicilian town: Further evidence for iatrogenic transmission

2002

The prevalence of and risk factors for HCV and HBV infections in the general population and the predictive value of ALT screening in identifying anti-HCV positive subjects have been evaluated in a small Sicilian town. A random 1:4 sampling from the census of the general population was performed. Anti-HCV, HCV-RNA, HCV genotype, HBsAg, and anti-HBc were tested. The linkage between HCV infection and potential risk factors was evaluated by multiple logistic regression analysis. Among 721 subjects studied, 75 (10.4%) were anti-HCV positive. The HCV infection rate increased from 0.4% in subjects 10-29 years of age to 34% in those > 60 years of age. Among the 75 anti-HCV positive subjects, 66.7% …

AdultMaleEndemic DiseasesAdolescentEpidemiologyIatrogenic DiseasePredictive Value of TestEndemic DiseaseHepacivirusAge DistributionPredictive Value of TestsRisk FactorsVirologyPrevalenceHumansChildSicilyAgedAged 80 and overHepaciviruRisk FactorGeneral populationAlanine TransaminaseHepatitis B viruHepatitis C AntibodiesMiddle AgedHepatitis BHepatitis CPopulation SurveillanceFemaleHepatitis C viruHepatitis C AntibodieHuman
researchProduct

Mortality risk according to different clinical characteristics of first episode of liver decompensation in cirrhotic patients: a nationwide, prospect…

2013

Abstract OBJECTIVES: The occurrence of decompensation marks a crucial turning point in the course of cirrhosis. The purpose of this study was to assess the risk of mortality according to the clinical characteristics of first decompensation, considering also the impact of acute-on-chronic liver failure (AoCLF). METHODS: We conducted a prospective nationwide inception cohort study in Italy. Decompensation was defined by the presence of ascites, either overt or detected by ultrasonography (UD), gastroesophageal variceal bleeding (GEVB), and hepatic encephalopathy (HE). AoCLF was defined according to the Asian Pacific Association for the Study of the Liver criteria. Multivariable Cox proportion…

AdultLiver CirrhosisMalemedicine.medical_specialtyPediatricsCarcinoma HepatocellularCirrhosisAdolescentmedicine.medical_treatmentCirrhosis Mortality Liver decompensation CohortLiver transplantationEsophageal and Gastric VaricesSeverity of Illness IndexYoung AdultSeverity of illnessmedicineHumansProspective StudiesYoung adultIntensive care medicineProspective cohort studyHepatic encephalopathyAgedProportional Hazards ModelsAged 80 and overFirst episodeHepatologybusiness.industryLiver NeoplasmsGastroenterologyAscitesMiddle Agedmedicine.diseaseLiver TransplantationAdolescent; Adult; Aged; Aged 80 and over; Ascites; Carcinoma Hepatocellular; Esophageal and Gastric Varices; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hepatic Encephalopathy; Humans; Italy; Liver Cirrhosis; Liver Failure; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Prospective Studies; Severity of Illness Index; Young AdultItalyCirrhosisHepatic EncephalopathyMultivariate AnalysisCohortFemaleGastrointestinal HemorrhagebusinessLiver FailureFollow-Up Studies
researchProduct

Gender differences in chronic HBsAg carriers in Italy: Evidence for the independent role of male sex in severity of liver disease

2015

It has been shown that sexual hormones have an opposite effect on hepatic fibrosis progression and hepatocellular carcinoma development. Sex differences among 2,762 chronic HBsAg carriers consecutively referring Italian hospitals in 2001 and in 2007 have been evaluated, particularly focusing on the role of gender on severity of liver disease. The overall sex ratio (males/females) was 2.6. Females were more likely born abroad and new diagnosis cases; but less likely HIV coinfected. No sex difference was observed regarding coinfection with other hepatitis viruses. The sex ratio linearly increased with increasing severity of liver disease, being 1.3 in normal ALT, 2.8 in chronic hepatitis, 3.6…

Liver CirrhosisAdultMaleChronic HBsAg carriers; Cirrhosis; Hepatocellular carcinoma; Sex differences; Adult; Aged; Carcinoma Hepatocellular; Female; Hepatitis B Surface Antigens; Hepatitis B Chronic; Humans; Italy; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Sex Factors; Virology; Infectious DiseasesCarcinoma HepatocellularHepatocellular carcinomaLiver CirrhosiHepatitis B Surface AntigenChronic HBsAg carriersHepatitis B ChronicSex FactorsVirologySex differencesHumansChronicAgedChronic HBsAg carrierHepatitis B Surface AntigensCirrhosiCarcinomaLiver NeoplasmsHepatocellularMiddle AgedHepatitis BSex differenceInfectious DiseasesCirrhosisItalyLiverLiver NeoplasmFemaleHuman
researchProduct