0000000000520378

AUTHOR

Paula Gameiro

0000-0002-4747-6853

showing 3 related works from this author

Fluoroquinolone–metal complexes: A route to counteract bacterial resistance?

2014

Abstract Microbial resistance to antibiotics is one of the biggest public health threats of the modern world. Antibiotic resistance is an area of much clinical relevance and therefore research that has the potential to identify agents that may circumvent it or treat resistant infections is paramount. Solution behavior of various fluoroquinolone (FQ) complexes with copper(II) in the presence and absence of 1,10-phenanthroline (phen) was studied in aqueous solution, by potentiometry and/or spectrophotometry, and are herein described. The results obtained showed that under physiological conditions (micromolar concentration range and pH 7.4) only copper(II):FQ:phen ternary complexes are stable.…

Stereochemistrychemistry.chemical_elementInfrared spectroscopyMicrobial Sensitivity TestsCrystallography X-RayBiochemistryInorganic ChemistryMetalMinimum inhibitory concentrationCoordination ComplexesSpectrophotometryDrug Resistance BacterialEscherichia colimedicineMoleculeAqueous solutionmedicine.diagnostic_testChemistryCombinatorial chemistryCoppervisual_artvisual_art.visual_art_mediumTernary operationCopperFluoroquinolonesPhenanthrolinesJournal of Inorganic Biochemistry
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CCDC 990231: Experimental Crystal Structure Determination

2014

Related Article: Maria J. Feio, Isabel Sousa, Mariana Ferreira, Luís Cunha-Silva, Raúl G. Saraiva, Carla Queirós, José G. Alexandre, Vasco Claroa, AdéliaMendes, RosaOrtiz, Sandra Lopes, Ana Luísa Amaral, João Lino, Patrícia Fernandes, Ana João Silva, Lisete Moutinho, Baltazar de Castro, Eulália Pereira, Lourdes Perelló, Paula Gameiro|2014|J.Inorg.Biochem.|138|129|doi:10.1016/j.jinorgbio.2014.05.007

Space GroupCrystallographyaqua-(9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-(oxo)-23-dihydro-7H-[14]oxazino[234-ij]quinoline-6-carboxylato)-(110-phenanthroline)-copper(ii) nitrate dihydrateCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 990233: Experimental Crystal Structure Determination

2014

Related Article: Maria J. Feio, Isabel Sousa, Mariana Ferreira, Luís Cunha-Silva, Raúl G. Saraiva, Carla Queirós, José G. Alexandre, Vasco Claroa, AdéliaMendes, RosaOrtiz, Sandra Lopes, Ana Luísa Amaral, João Lino, Patrícia Fernandes, Ana João Silva, Lisete Moutinho, Baltazar de Castro, Eulália Pereira, Lourdes Perelló, Paula Gameiro|2014|J.Inorg.Biochem.|138|129|doi:10.1016/j.jinorgbio.2014.05.007

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-14-dihydroquinoline-3-carboxylato)-(110-phenanthroline)-copper(ii) nitrate trihydrateExperimental 3D Coordinates
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