0000000000522400
AUTHOR
Felice Femiano
Burning mouth syndrome (BMS) : evaluation of thyroid and taste
Background Burning mouth syndrome (BMS) is a chronic, intraoral burning sensation seen mainly in middle-aged and post-menopausal females, without identifiable oral lesions or abnormal laboratory findings, but often associated with psychogenic disorders such as depression. The latter can have a range of causes, including hormonal. Objective Since there may be connections between BMS, psychogenic changes, hormonal changes and taste abnormalities , we have examined aspects of taste and thyroid function.. Patients and methods We selected 50 patients with BMS (study group) and 50 healthy subjects (control group) and analysed their ability to taste bitter, acid and spicy substances and analysed t…
Síndrome de boca ardiente: estudio de la psicoterapia, medicación con ácido alfa- lipoico y combinación de terapias
En este estudio de 192 personas sanas con Síndrome de boca ardiente, se analizó la eficacia del control de los síntomas de la psicoterapia sola durante dos sesiones semanales de 1 hora durante dos meses, del ácido alfa lipoico (ALA, ácido tioctico, Tiobec) 600 mg al día durante dos meses, y de la combinación de la psicoterapia y los 600 mg / día de ALA durante 2 meses. Los controles solo recibieron placebo. RESULTADOS. Se obtuvo el mayor beneficio con la terapia combinada. La combinación de los tratamientos con psicoanálisis y ácido alfa lipoico (ALA, acido tioctico, Tiobec 600 mgr al día), durante 2 meses fue significativamente más beneficiosa que el psicoanálisis solo durante dos sesiones…
Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris.
We have previously demonstrated that serum of patients with pemphigus vulgaris induces reduction of desmoglein 3 (Dsg3) half-life in keratinocytes (FEBS Lett 2006: 580: 3276). This phenomenon seems to occur as a consequence of the progressive depletion of Dsg3 from desmosomes. Here we reported that reduction of full-length Dsg3 may be due to its progressive cleavage, leading to the formation of two fragmentation products with apparent molecular masses of about 60 kDa (fragment 1) and 70 kDa (fragment 2), as revealed by Western blotting. Unexpectedly, analysis of fragmentation pattern suggested cleavage to occur intracellularly. Consistently, fragment 1 was shed and localized within the cyto…
Burning mouth disorder (BMD) and taste: a hypothesis
Background: Burning mouth disorder (BMD) is a burning or stinging sensation affecting the oral mucosa, lips, and/ or tongue, in the absence of clinically visible mucosal lesions. There is a strong female predilection, with the age of onset being approximately 50 years. The causes of BMD are multifactorial and remain poorly understood. Often BMD patients report, in association, change in taste. In this regards, it is relevant that in central nervous system connections exist between taste and oral pain and that taste normally inhibits oral pain. Aim: The working hypothesis of this study considers a possible relationship between burning mouth disorders and alterations of taste. Several conditi…