0000000000523956

AUTHOR

Dominic O. Ochwang’i

showing 2 related works from this author

Cytotoxic activity of medicinal plants of the Kakamega County (Kenya) against drug-sensitive and multidrug-resistant cancer cells

2018

Abstract Ethnopharmacological relevance The geographical location of Kakamega County proximal to the Kakamega Rain Forest in Kenya and its rich flora represents an interesting resource of traditional medicinal plants. The medicinal plants in the present study are traditionally used to treat cancer in Kakamega County as recorded in published literature. Aim of the study Due to multidrug resistance (MDR) and severe side effects of currently used drugs in clinical oncology, new candidate compounds are urgently required to improve treatment outcome. The present study explored the in vitro cytotoxic potential of 34 organic and 19 aqueous extracts of Kakamega medicinal plants towards sensitive an…

0301 basic medicinePhyllanthusCell SurvivalDrug resistancePharmacognosyInhibitory Concentration 5003 medical and health sciences0302 clinical medicineCell Line TumorOxazinesDrug DiscoveryHarunganaATP Binding Cassette Transporter Subfamily G Member 2HumansATP Binding Cassette Transporter Subfamily B Member 1Medicinal plantsMedicine African TraditionalPharmacologyPrunus africanaPlants MedicinalbiologyTraditional medicineBridelia micranthabiology.organism_classificationAntineoplastic Agents PhytogenicNeoplasm ProteinsErbB ReceptorsGene Expression Regulation NeoplasticMultiple drug resistance030104 developmental biologyXanthenesDrug Resistance Neoplasm030220 oncology & carcinogenesisDrug Therapy CombinationJournal of Ethnopharmacology
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Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts.

2017

Abstract Background Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism. Hypothesis The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe. Study design Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communiti…

Complementary TherapiesQuality ControlInternational CooperationPopulationPharmaceutical ScienceTheftLegislationSelf MedicationColonialismIndigenousPatents as Topic03 medical and health sciences0302 clinical medicineDouble-Blind MethodPolitical scienceDrug DiscoveryHealth careHumansNagoya ProtocolEuropean UnionTraditional knowledgeeducationDeveloping Countries030304 developmental biologyPharmacology0303 health scienceseducation.field_of_studyEvidence-Based MedicinePlants Medicinalbusiness.industryEvidence-based medicineBiodiversityPublic relationsComplementary and alternative medicine030220 oncology & carcinogenesisNaturopathyMolecular MedicineIntegrative medicineMedicine TraditionalbusinessPhytomedicine : international journal of phytotherapy and phytopharmacology
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