0000000000524111
AUTHOR
D. Zöller
NOROVIRUS GASTROENTERITIS IS AN IMPORTANT CAUSE OF NOSOCOMIAL INFECTIONS IN GERMANY
Noroviruses are the most important global cause of acute gastroenteritis (AGE). Testing for norovirus in patients hospitalized with AGE is incentivized in Germany because a positive diagnosis impacts reimbursement. We estimated the number of nosocomial infections overall and by age-group for norovirus gastroenteritis (NGE) using federal German databases. All hospitalizations in Germany are registered with the German Federal Statistics Office (DESTATIS). We extracted aggregate data for patients hospitalized with NGE (ICD-10 codes A08.1) as primary or non-primary diagnosis for the period 2007–2012. Cases with a non-primary diagnoses were assumed to be due to nosocomial infection.
Improved prediction of survival by a risk factor-integrated inflammatory score in Sorafenib treated hepatocellular carcinoma
Background and aims Inflammation affects progression of hepatocellular carcinoma (HCC). We therefore postulate that systemic inflammatory markers could help to predict prognosis in HCC patients receiving sorafenib therapy. Methods Overall survival (OS) of HCC patients receiving palliative sorafenib treatment was correlated with the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein to albumin ratio (CAR), Glasgow prognostic score (GPS) and the modified GPS (mGPS) along with clinicopathological parameters. Predictors of OS were assessed by multivariable Cox regression and receiver operating characteristics and area under the curve (ROC-AUC) analyses.…