0000000000524117

AUTHOR

K. Geldnere

showing 2 related works from this author

Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes

2013

Variations in the FTO gene and near the TMEM18 gene are risk factors for common form of obesity, but have also been linked with type 2 diabetes (T2D). Our aim was to investigate the contribution of these variants to risk of T2D in a population in Latvia. Four single nucleotide polymorphisms (SNP) in the first and fourth intronic regions of FTO and one close to TMEM18 were genotyped in 987 patients with T2D and 1080 controls selected from the Latvian Genome Data Base (LGDB). We confirmed association of SNPs in the first intron (rs11642015, rs62048402 and rs9939609) of FTO and rs7561317 representing the TMEM18 locus with T2D. Association between SNP in FTO and T2D remained significant after c…

Linkage disequilibriumendocrine system diseasesPopulationAlpha-Ketoglutarate-Dependent Dioxygenase FTOSingle-nucleotide polymorphismLocus (genetics)Genome-wide association studyBiologyPolymorphism Single NucleotideFTO geneGeneticsmedicineHumansSNPAge of OnseteducationGeneticseducation.field_of_studyAge FactorsMembrane ProteinsProteinsnutritional and metabolic diseasesGeneral Medicinemedicine.diseaseObesityDiabetes Mellitus Type 2Gene
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Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population

2012

Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for type 2 diabetes (T2D) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia. We genotyped 4 single nucleotide polymorphisms (SNP) rs7901695, rs7903146, rs11196205 and rs12255372 in 1 093 controls and 1 043 diabetic subjects. Association with T2D was found for 3 SNPs rs7901695, rs7903146 and rs12255372 in the whole sample (under an additive genetic model, the adjusted odds ratios (OR) were 1.26, 95% CI [1.08-1.48], P=0.003; OR=1.32, 95% CI [1.12-1.5…

Maleendocrine systemendocrine system diseasesEndocrinology Diabetes and MetabolismPopulationSingle-nucleotide polymorphismType 2 diabetesBiologyPolymorphism Single NucleotideBody Mass IndexEndocrinologyPolymorphism (computer science)Databases GeneticGenetic modelInternal MedicinemedicineHumansSNPGenetic Predisposition to DiseaseObesityeducationGenetic Association StudiesGeneticseducation.field_of_studynutritional and metabolic diseasesGeneral MedicineOdds ratioMiddle Agedmedicine.diseaseLatviaDiabetes Mellitus Type 2Case-Control StudiesFemaleTranscription Factor 7-Like 2 ProteinTCF7L2Experimental and Clinical Endocrinology & Diabetes
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