0000000000524180

AUTHOR

Marcelo Augusto Junior Garcia

showing 1 related works from this author

Revisiting the metallothionein genes polymorphisms and the risk of oral squamous cell carcinoma in a Brazilian population

2020

Background Metallothioneins (MTs) gene polymorphisms have been associated with the ability of free radical scavenging and detoxification of heavy metals leading to cancer development. Our aim was to revisit, in a Brazilian population, single-nucleotide polymorphisms (SNPs) of the MT gene family previously associated with oral squamous cell carcinoma (OSCC). Material and Methods A case-control investigation with 28 OSCC patients and 45 controls was conducted, using conventional risk factors (tobacco use and alcohol consumption) as covariates. SNPs genotyping for rs8052334 (MT1B), rs964372 (MT1B), and rs1610216 (MT2A) was performed by PCR-RFLP, and SNPs for rs11076161 (MT1A) were analyzed by …

Oncologymedicine.medical_specialtyLinkage disequilibriumGenotypePopulationSingle-nucleotide polymorphismBiologygallium aluminium arsenide lasersPolymorphism Single NucleotideRisk FactorsOral Cancer and Potentially malignant disordersInternal medicineGenotypemedicineHumansSNPGenetic Predisposition to Diseasethird molareducationGeneral DentistryGenotypingUNESCO:CIENCIAS MÉDICASeducation.field_of_studycontrolled clinical trialSquamous Cell Carcinoma of Head and NeckResearchHaplotypestomatognathic diseasesOtorhinolaryngologyHead and Neck NeoplasmsCase-Control StudiesCarcinoma Squamous CellMetallothioneinMouth NeoplasmsSurgeryGene polymorphismBrazilMedicina Oral Patología Oral y Cirugia Bucal
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