0000000000524648

AUTHOR

M. Alessio

showing 3 related works from this author

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study

2017

Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients. Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012. Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n = 88) and 2.2 years in those treated with zoledronate (n = 218). Multiv…

MalebisphosphonateTime Factorsmedicine.medical_treatmentOsteoporosis0302 clinical medicineRisk Factors80 and overosteoporosijaw osteonecrosiAged 80 and overBone Density Conservation AgentsDiphosphonatesjaw osteonecrosisjaw osteonecrosis bisphosphonates breast cancer multiple myeloma prostate cance osteoporosisIncidenceIncidence (epidemiology)Otorhinolaryngology2734 Pathology and Forensic MedicineMiddle Agedprostate cancermultiple myeloma030220 oncology & carcinogenesisBisphosphonate-Associated Osteonecrosis of the JawFemaleAdultmedicine.medical_specialty2734Drug Administration SchedulePathology and Forensic Medicine03 medical and health sciencesbreast cancerbisphosphonates; breast cancer; jaw osteonecrosis; multiple myeloma; osteoporosis; prostate cancer; Adult; Aged; Aged 80 and over; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation Agents; Cross-Sectional Studies; Diphosphonates; Drug Administration Schedule; Female; Humans; Incidence; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Otorhinolaryngology; 2734; Pathology and Forensic Medicine; Dentistry (all)Internal medicinemedicineHumansBisphosphonates; Breast cancer; Jaw osteonecrosis; Multiple myeloma; Osteoporosis; Prostate cancer; Otorhinolaryngology2734 Pathology and Forensic Medicine; Dentistry (all)prostate canceAdverse effectGeneral DentistrybisphosphonatesAgedProportional Hazards ModelsRetrospective StudiesBisphosphonate-associated osteonecrosis of the jawbusiness.industryProportional hazards modelRetrospective cohort study030206 dentistryBisphosphonatemedicine.diseaseosteoporosisSurgeryCross-Sectional StudiesOtorhinolaryngologyMultivariate AnalysisDentistry (all)businessOsteonecrosis of the jaw
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TASSO DI PERSISTENZA IN TERAPIA E FATTORI PREDITTIVI DI SOPRAVVIVENZA DEGLI INIBITORI DELL’INTERLEUCHINA 1 NELL’ARTRITE IDIOPATICA GIOVANILE A ESORDI…

2019

INTRODUZIONE L’introduzione dei farmaci biologici ha rivoluzionato l’approccio terapeutico nell’Artrite Idiopatica Giovanile a esordio Sistemico (SoJIA), modificando la storia naturale di questa malattia e migliorandone l’outcome globale. METODI Obiettivo principale dello studio era analizzare il tasso di persistenza in terapia (DRR) degli inibitori dell’Interleuchina (IL)-1 nei pazienti affetti da SoJIA. Obiettivi secondari dello studio erano: (1) esplorare l’influenza della linea biologica di trattamento, degli eventi avversi, dello specifico agente anti-IL-1 e del cotrattamento con disease modifying anti-rheumatic drugs (cDMARDs) sul DRR; (2) identificare eventuali fattori predittivi ass…

Settore MED/38 - Pediatria Generale E SpecialisticaFATTORI PREDITTIVI DI SOPRAVVIVENZA INTERLEUCHINA 1 ARTRITE IDIOPATICA GIOVANILE
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Adherence to colchicine treatment and colchicine resistance in a multicentric FMF national cohort

2020

Introduction: Colchicine is the standard treatment for Familiar Mediterranean Fever (FMF), however about 5% of patients (pts) experience colchicine resistance. There is no standard definition of colchicine resistance. Recently a panel of experts elaborated a new definition based on a Delphi consensus approach. Objectives: We aim to describe main features of the disease and clinical outcome of a cohort of FMF pts with particular interest on the colchicine resistance and tolerability according to the definitions proposed by the recent consensus.

Settore MED/38 - Pediatria Generale E SpecialisticaColchicine resistance Familiar Mediterranean Fever Delphi consensus approach
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