0000000000525081
AUTHOR
S. Klein
Activity of O 6 -methylguanine DNA methyltransferase in mononuclear blood cells of formaldehyde-exposed medical students
A recent study reported that exposure of student embalmers in Cincinnati to high concentrations of formaldehyde (2 mg/m3) reduced the activity of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT). Reduction in a DNA repair enzyme may strongly increase the cancer risk not only with respect to the repair-enzyme causing agent but with respect to all carcinogens causing lesions subject to repair by the enzyme in question. Thus, we examined whether formaldehyde exposure of 57 medical students during their anatomy course at two different Universities in Germany influenced MGMT activity in mononuclear blood cells. Mean formaldehyde exposure of 41 students was 0.2 +/- 0.05 mg/m3 …
HΛ3 and H‾Λ¯3 production in Pb–Pb collisions at sNN=2.76 TeV
Abstract The production of the hypertriton nuclei H Λ 3 and H ‾ Λ ¯ 3 has been measured for the first time in Pb–Pb collisions at s NN = 2.76 TeV with the ALICE experiment at LHC. The p T -integrated H Λ 3 yield in one unity of rapidity, d N / d y × B . R . ( H Λ 3 → He 3 , π − ) = ( 3.86 ± 0.77 ( stat. ) ± 0.68 ( syst. ) ) × 10 − 5 in the 0–10% most central collisions, is consistent with the predictions from a statistical thermal model using the same temperature as for the light hadrons. The coalescence parameter B 3 shows a dependence on the transverse momentum, similar to the B 2 of deuterons and the B 3 of 3He nuclei. The ratio of yields S 3 = H Λ 3 / ( He 3 × Λ / p ) was measured to b…
The 16O(γ, 2N) reaction measured with tagged photons
The results of tagged-photon measurements of the 4He(γ, pn)d, 4He(γ, pn)pn and 4He(γ, pp)nn reactions, carried out with photons of energies 80–131 MeV, are presented. The (γ, pn)d three-body-breakup cross section dominates the four-body-breakup cross section. The three-body-breakup cross section and the corresponding deuteron recoil-momentum spectrum are reasonably accounted for by a mechanism of photon absorption on correlated proton-neutron pairs. In contrast the four-body-breakup mechanism appears to have two components: absorption on correlated proton-neutron pairs and a more complex additional component which has a distribution similar to phase space. The data rule out substantial phot…
First measurement of the |t|-dependence of coherent J/ψ photonuclear production
The first measurement of the dependence on $|t|$, the square of the momentum transferred between the incoming and outgoing target nucleus, of coherent J/ψ photoproduction is presented. The data were measured with the ALICE detector in ultra-peripheral Pb-Pb collisions at a centre-of-mass energy per nucleon pair $\sqrt{s_{\rm NN}} = 5.02$ TeV with the J/$\psi$ produced in the central rapidity region $|y| < 0.8$, which corresponds to the small Bjorken-$x$ range $(0.3 − 1.4) \times 10 ^{−3}$. The measured $|t|$-dependence is not described by computations based only on the Pb nuclear form factor, while the photonuclear cross section is better reproduced by models including shadowing according t…
A new assay for O6-alkylguanine-DNA-alkyltransferase to determine DNA repair capacities using lambda-phage DNA as substrate.
One O6-methylguanine (O6-meG) was introduced into each BamHI site of lambda-phage DNA as a substrate for the determination of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase. A new assay using as the detection group 32P-labeled phosphate introduced at the 3' position of the modified nucleoside by incorporation of 32P-labeled TTP in the 3'-neighboring position proved highly sensitive: 10(-16) mol of the DNA lesion was still easily detectable. This DNA, which has greater than 1000 bp represents a good model for cellular DNA and was used as a substrate to measure the individual repair capacities for O6-meG in human lymphocytes of 20 healthy male and female donors. There were great …
Real-time data processing in the ALICE High Level Trigger at the LHC
At the Large Hadron Collider at CERN in Geneva, Switzerland, atomic nuclei are collided at ultra-relativistic energies. Many final-state particles are produced in each collision and their properties are measured by the ALICE detector. The detector signals induced by the produced particles are digitized leading to data rates that are in excess of 48 GB/$s$. The ALICE High Level Trigger (HLT) system pioneered the use of FPGA- and GPU-based algorithms to reconstruct charged-particle trajectories and reduce the data size in real time. The results of the reconstruction of the collision events, available online, are used for high level data quality and detector-performance monitoring and real-tim…
Search for a common baryon source in high-multiplicity pp collisions at the LHC
Physics letters / B B811, 135849 (2020). doi:10.1016/j.physletb.2020.135849
Dielectron production in proton-proton and proton-lead collisions at √sNN=5.02TeV
The first measurements of dielectron production at midrapidity (|ηe| < 0.8) in proton–proton and proton–lead collisions at √sNN = 5.02 TeV at the LHC are presented. The dielectron cross section is measured with the ALICE detector as a function of the invariant mass mee and the pair transverse momentum pT, ee in the ranges mee < 3.5 GeV/c2 and pT, ee < 8 GeV/c, in both collision systems. In proton–proton collisions, the charm and beauty cross sections are determined at midrapidity from a fit to the data with two different event generators. This complements the existing dielectron measurements performed at √s = 7 and 13 TeV. The slope of the √s dependence of the three measurements is…
Heavy flavour production at the LHC: Theoretical Aspects
CERN-DESY workshop on "HERA and the LHC" DESY-PROC-2009-02; ISBN 978-3-935702-32-4; ISSN 1435-8077; International audience; A proper inclusion of heavy quark mass effects in Parton Distribution Function fits has proved crucial. We present a review these effects in DIS and their impact on global analyses and lay out all elements of a properly defined general mass variable flavor number scheme (GM VFNS) that are shared by all modern formulations of the problem. We also report about progress in a number of theoretical problems related to exclusive measurements of heavy flavors. These topics include fragmentation functions for charmed mesons including finite mass effects, fragmentation function…
Study of non-fusion products in the 50Ti + 249Cf reaction
Physics letters / B B 784, 199 - 205 (2018). doi:10.1016/j.physletb.2018.07.058
Electron Ion Collider: The Next QCD Frontier: Understanding the glue that binds us all
International audience; This White Paper presents the science case of an Electron-Ion Collider (EIC), focused on the structure and interactions of gluon-dominated matter, with the intent to articulate it to the broader nuclear science community. It was commissioned by the managements of Brookhaven National Laboratory (BNL) and Thomas Jefferson National Accelerator Facility (JLab) with the objective of presenting a summary of scientific opportunities and goals of the EIC as a follow-up to the 2007 NSAC Long Range plan. This document is a culmination of a community-wide effort in nuclear science following a series of workshops on EIC physics over the past decades and, in particular, the focus…
Measurements of mixed harmonic cumulants in Pb–Pb collisions at sNN=5.02 TeV
Correlations between moments of different flow coefficients are measured in Pb–Pb collisions at sNN=5.02 TeV recorded with the ALICE detector. These new measurements are based on multiparticle mixed harmonic cumulants calculated using charged particles in the pseudorapidity region |η|<0.8 with the transverse momentum range 0.2<pT<5.0 GeV/c. The centrality dependence of correlations between two flow coefficients as well as the correlations between three flow coefficients, both in terms of their second moments, are shown. In addition, a collection of mixed harmonic cumulants involving higher moments of v2 and v3 is measured for the first time, where the characteristic signature of ne…
Study of non-fusion products in the Ti50+Cf249 reaction
The isotopic distribution of nuclei produced in the 50Ti + 249Cf reaction has been studied at the gas-filled recoil separator TASCA at GSI Darmstadt, which separates ions according to differences in magnetic rigidity. The bombardment was performed at an energy around the Bass barrier and with the TASCA magnetic fields set for collecting fusion-evaporation reaction products. Fifty-three isotopes located “north-east” of 208Pb were identified as recoiling products formed in non-fusion channels of the reaction. These recoils were implanted with energies in two distinct ranges; besides one with higher energy, a significant low-energy contribution was identified. The latter observation was not ex…
"Table 2" of "The 16O(��, 2N) reaction measured with tagged photons"
PROPOSED THAT THE REACTION IS DUE TO A QUASI DEUTERON MECHANISM AND P N PAIRS E]ECT FROM THE 1P SHELL.
"Table 1" of "The 16O(��, 2N) reaction measured with tagged photons"
PROPOSED THAT THE REACTION IS DUE TO A QUASI DEUTERON MECHANISM AND P N PAIRS E]ECT FROM THE 1P SHELL.