Rilevanza clinica delle interazioni farmacologiche di tipo farmacocinetico [Clinical significance of pharmacokinetic interactions]

The correct realization of a pharmacological therapy needs the individuation of the most appropriate drugs for the treatment of the patient's disease. However, even the most effective, and potent and appropriate drugs cannot assure the therapeutic success, if that compound does not reach the site of action. This result can be obtained only if the physician knows the factors that regulate thepharmacokinetic parameters of the used drugs, i.e. absorption, distribution, metabolism, excretion, that regulate the onset velocity, the duration and the intensity of the drug effects. In the lost years, pharmacological interactions, i.e. the possibility that co-administered drugs interfere with each ot…

Chronic prenatal treatment with 5-methoxytryptamine reduced depressive-like behaviour induced by forced swim test in mature male rats

Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring.

A reduction in 5-HT1A receptor response enhances learning and memory performance in rats. Pre- and postnatal treatment with 5-methoxytryptamine (5MT), a non-selective serotonergic agonist, and early handling, reduce the number of 5-HT1A receptors in neonatal and pre-pubertal rat progeny. The aim of this study was to investigate in adolescent male rats the consequences of pre- and postnatal treatment with 5MT and its interaction with early handling on an object-place association learning task, the "Can test", a motivated, non-aversive, spatial/object discrimination task. Results show that a single daily injection of 5MT from gestational days 12 to 21 (1 mg/kg s.c.) and from postnatal days 2 …

Manipulations of glucocorticoid induced stress response may differently affect the acquisition of a reward-facilitated spatial-visual learning task.

Manipulations of glucocorticoids induced stress response may differently affect the acquisition of a reward-facilitated spatially/visual learning task.

Perinatal treatment with 5-methoxytriptamine affects cognition and behavioural reactivity in the juvenile male rat progeny: influence of maternal separation

Single intense prenatal stress reduce behavioural suppression in an operant conflict paradigm in the adult progeny. Influence of Metyrapone administration

Stressors presented during late prenatal period can have long-term effects on offspring behaviour (1). Indeed we showed that in the rat progeny a single immobilization procedure at gestational day 16 enhances spatial learning in a non-aversive, rewarded-facilitated learning task, the Can Test, and decreases anxiety-like behaviour in the elevated plus maze (2). In this study, we wanted to investigate: (i) the effects of a single prenatal immobilization-stress on the operant conflict task (OCT), an anxiety-related procedure, in which positively reinforced responses are suppressed by contingent punishment (3); (ii) the expression of mineralcorticoid and glucocorticoid receptors (MRs, GRs) in t…

Perinatal Treatment with 5-metoxytriptamine affects cognition and behavioural reactivity in the juvenile male rat progeny; influence of maternal separation

Gender-related effects on emotionality, learning and memory performance in adult rats

Reversal of prenatal diazepam-induced deficit in spatial-object learning task by brief, periodic maternal separation in adult male rats

Pregnenolone sulphate faciltates object recognition and reduces depressive-like behaviour in male adult rats

Manipulatios of glucocortioid induced stress response may differently affect the acquisition of a reward-facilitated spatial/visual learning task

Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: Interaction with a brief, daily maternal separation.

Perinatal manipulations can lead to neurobehavioural changes in the progeny. In this study we investigated, in adolescent male rat offspring, the consequences of a single, intense prenatal stress induced by a 120 min-maternal immobilization at gestational day 16, and of a daily, brief maternal separation from postnatal day 2 until 21, on: unconditioned fear/anxiety-like behaviour in open field and in elevated plus-maze; learning performance in the "Can test", a non-aversive spatial and tactile/visual task; corticosterone plasma levels under basal and stress-induced conditions. Our results indicate that both prenatal stress and maternal separation procedures decrease emotionality and enhance…

Reversal of prenatal diazepam-induced deficit in a spatial-object learning task by brief, periodic maternal separation in adult rats.

In the rat, prenatal exposure to diazepam (DZ) induces a permanent reduction in GABA/BZ receptor (R) function and behavioural abnormalities. Environmental modifications during early stages of life can influence brain development and induce neurobiological and behavioural changes throughout adulthood. Indeed, a subtle, periodic, postnatal manipulation increases GABA/BZ R activity and produces facilitatory effects on neuroendocrine and behavioural responses. We here investigated the impact of prenatal treatment with DZ on learning performance in adult 3- and 8-month-old male rats and the influence of a brief, periodic maternal separation on the effects exerted by prenatal DZ exposure. Learnin…

Gender-related affects of pregs on emotional, learning and memory performance in adult rats

The neurosteroids sulfate pregs and DHEAS selectively improve memory retention in adult female rats

Neurosteroid PREGS differently affects learning and memory performance by altering emotionality in a gender-related manner

Gender-related effects of PREGS on emotionality, learning and memory performance in adult rats.

Chronic perinatal treatment with 5-methoxytryptamine reduces depressive-like behaviour induced by forced swim in mature male rats

Gender-related effects on emotionality, learning and memory performance in adult rats. 33° Congresso Società Italiana Farmacologia.

The neurosteroids PREGS and DHEAS selectively improve memory retention in adult female rats.

Perinatal exposure to 5-methoxytryptamine, behavioural-stress reactivity and functional response of 5-HT1A receptors in the adolescent rat.

Abstract Serotonin is involved in a wide range of physiological and patho-physiological mechanisms. In particular, 5-HT1A receptors are proposed to mediate stress-adaptation. The aim of this research was to investigate in adolescent rats: first, the consequences of perinatal exposure to 5-metoxytryptamine (5MT), a 5-HT1/5-HT2 serotonergic agonist, on behavioural-stress reactivity in elevated plus maze, open field and forced swim tests; secondly, whether the behavioural effects induced by perinatal exposure to 5MT on open field and forced swim tests were affected by the selective 5-HT1A receptor agonist LY 228729, a compound able to elicit a characteristic set of motor behaviours on these ex…

La psicofarmacologia nei bambini in età scolare e pre-scolare