Author: Simona Corso

0000000000528832

AUTHOR

Simona Corso

showing 4 related works from this author

Additional file 2 of hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers

2022

Additional file 2.

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Additional file 1 of hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers

2022

Additional file 1.

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Additional file 3 of hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers

2022

Additional file 3.

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hOA-DN30: a highly effective humanized single-arm MET antibody inducing remission of ‘MET-addicted’ cancers

2022

Abstract Background The tyrosine kinase receptor encoded by the MET oncogene is a major player in cancer. When MET is responsible for the onset and progression of the transformed phenotype (MET-addicted cancers), an efficient block of its oncogenic activation results in potent tumor growth inhibition. Methods Here we describe a molecular engineered MET antibody (hOA-DN30) and validate its pharmacological activity in MET-addicted cancer models in vitro and in vivo. Pharmacokinetics and safety profile in non-human primates have also been assessed. Results hOA-DN30 efficiently impaired MET activation and the intracellular signalling cascade by dose and time dependent removal of the receptor fr…

Cancer ResearchTumorCorrectionProto-Oncogene Proteins c-metCell LineTargeted therapyMiceAntibody; Gastric cancer; MET oncogene; Targeted therapy; Animals; Cell Line Tumor; Cell Proliferation; Humans; Mice; Signal Transduction; Proto-Oncogene Proteins c-met; Stomach NeoplasmsOncologyStomach NeoplasmsCell Line TumorMET oncogeneAnimalsHumansGastric cancerAntibodyCell ProliferationSignal TransductionJournal of Experimental & Clinical Cancer Research

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