0000000000530331

AUTHOR

Guillaume Reocreux

showing 1 related works from this author

Increased Phospholipid Transfer Protein Activity Is Associated With Markers of Enhanced Lipopolysaccharide Clearance in Human During Cardiopulmonary …

2021

Introduction: Lipopolysaccharide (LPS) is a component of gram-negative bacteria, known for its ability to trigger inflammation. The main pathway of LPS clearance is the reverse lipopolysaccharide transport (RLT), with phospholipid transfer protein (PLTP) and lipoproteins playing central roles in this process in experimental animal models. To date, the relevance of this pathway has never been studied in humans. Cardiac surgery with cardiopulmonary bypass is known to favor LPS digestive translocation. Our objective was to determine whether pre-operative PLTP activity and triglyceride or cholesterol-rich lipoprotein concentrations were associated to LPS concentrations in patients undergoing ca…

medicine.medical_specialtyLipopolysaccharideInflammationLipopolysaccharideCardiovascular Medicine030204 cardiovascular system & hematology[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologyLipopolysaccharide transport03 medical and health scienceschemistry.chemical_compound0302 clinical medicineHigh-density lipoproteinPhospholipid transfer proteinInternal medicineDiseases of the circulatory (Cardiovascular) systemMedicineLipoproteinOriginal Research030304 developmental biologyInflammation0303 health sciencesTriglyceridebusiness.industryCholesterolCardiopulmonary bypass[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biologyEndotoxemia3. Good healthEndocrinologychemistryRC666-701Phospholipid transfer protein (PLTP)lipids (amino acids peptides and proteins)medicine.symptomCardiology and Cardiovascular MedicinebusinessLipoprotein
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