0000000000530770
AUTHOR
Yong Wang
C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function
Background: Acute myocardial infarction (MI) elicits an inflammatory response that drives tissue repair and adverse cardiac remodeling. Inflammatory cell trafficking after MI is controlled by C-X-C motif chemokine ligand 12 (CXCL12) and its receptor, C-X-C motif chemokine receptor 4 (CXCR4). CXCR4 antagonists mobilize inflammatory cells and promote infarct repair, but the cellular mechanisms are unclear. Methods: We investigated the therapeutic potential and mode of action of the peptidic macrocycle CXCR4 antagonist POL5551 in mice with reperfused MI. We applied cell depletion and adoptive transfer strategies using lymphocyte-deficient Rag1 knockout mice; DEREG mice, which express a diphth…
Exploring the intersection of e-commerce and context in family business in China: the effects on organisational form and identity
This chapter melds these interests of understanding how the context of e-Commerce and family business affects organisational form and subsequently organisational identity by integrating a narrative about the development of family business and e-Commerce in China with an exploratory analysis of two Chinese family businesses. Institutional theory informs this discussion (Scott, 2008: Suddaby, Elsbach, Greenwood, Meyer and Zilber, 2010). After describing why businesses adopt e-Commerce, and illustrating the contextual conditions in China that foster the development of private enterprises such as family businesses, and the adoption of e-Commerce, the chapter subsequently explores the question “…
The intersection between family dynamics and e-commerce strategy in family businesses: Empirical investigation in China
This book chapter aims to contribute to increase our understanding of how e-Commerce strategy is designed, implemented, and influenced by family dynamics in family businesses, in China. Our research followed an exploratory and qualitative approach to analyse e-Commerce adoption by three Chinese family businesses, two of which were located in Beijing and one in Xinjiang. We used semi-structured interviews with key informants in the firms, focused on business history, business resources, as well as its corporate and e-Commerce strategies, and the family influence on the adoption of such strategies. The interviews were prepared based on the findings of a preliminary review of the literature on…
Observation of a class of disturbance in time series expansion for fractional order systems
Published version of an article in the journal: Abstract and Applied Analysis. Also available from the publisher at: http://dx.doi.org/10.1155/2014/874943 Open Access This paper is concerned with the problem of designing disturbance observer for fractional order systems, of which the disturbance is in time series expansion. The stability of a special observer with the selected nonlinear weighted function and transient dynamics function is rigorously analyzed for slowly varying disturbance. In addition, the result is also extended to estimate slope forms disturbance and higher order disturbance of fractional order systems. The efficacy of the proposed method is validated through numerical ex…
General output feedback stabilization for fractional order systems: An LMI approach
Published version of an article in the journal: Abstract and Applied Analysis. Also available from the publisher at: http://dx.doi.org/10.1155/2014/737495 Open Access This paper is concerned with the problem of general output feedback stabilization for fractional order linear time-invariant (FO-LTI) systems with the fractional commensurate order 0 < α < 2. The objective is to design suitable output feedback controllers that guarantee the stability of the resulting closed-loop systems. Based on the slack variable method and our previous stability criteria, some new results in the form of linear matrix inequality (LMI) are developed to the static and dynamic output feedback controllers synthe…
Active Disturbance Rejection Station-Keeping Control of Unstable Orbits around Collinear Libration Points
Published version of an article in the journal: Mathematical Problems in Engineering. Also available from the publisher at: http://10.1155/2014/410989 An active disturbance rejection station-keeping control scheme is derived and analyzed for station-keeping missions of spacecraft along a class of unstable periodic orbits near collinear libration points of the Sun-Earth system. It is an error driven, rather than model-based control law, essentially accounting for the independence of model accuracy and linearization. An extended state observer is designed to estimate the states in real time by setting an extended state, that is, the sum of unmodeled dynamic and external disturbance. This tota…
Constructing transient response probability density of non-linear system through complex fractional moments
Abstract The probability density function for transient response of non-linear stochastic system is investigated through the stochastic averaging and Mellin transform. The stochastic averaging based on the generalized harmonic functions is adopted to reduce the system dimension and derive the one-dimensional Ito stochastic differential equation with respect to amplitude response. To solve the Fokker–Plank–Kolmogorov equation governing the amplitude response probability density, the Mellin transform is first implemented to obtain the differential relation of complex fractional moments. Combining the expansion form of transient probability density with respect to complex fractional moments an…
Cu-Exchanged CHA-Type Zeolite from Organic Template-Free Synthesis: An Effective Catalyst for NH3-SCR
A Cu-containing CHA-type zeolite was prepared via aqueous ion exchange of the CHA zeolite from organic template-free synthesis. The thus-obtained template-free Cu-CHA showed the best catalytic perf...
Single intracerebroventricular progranulin injection adversely affects the blood–brain barrier in experimental traumatic brain injury
Progranulin (PGRN) is a neurotrophic and anti-inflammatory factor with protective effects in animal models of ischemic stroke, subarachnoid hemorrhage, and traumatic brain injury (TBI). Administration of recombinant (r) PGRN prevents exaggerated brain pathology after TBI in Grn-deficient mice, suggesting that local injection of recombinant progranulin (rPGRN) provides therapeutic benefit in the acute phase of TBI. To test this hypothesis, we subjected adult male C57Bl/6N mice to the controlled cortical impact model of TBI, administered a single dose of rPGRN intracerebroventricularly (ICV) shortly before the injury, and examined behavioral and biological effects up to 5 days post injury (dp…