0000000000533172

AUTHOR

Qian Zhao

showing 3 related works from this author

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study (Intensive…

2021

The original version of this article unfortunately contained a mistake. The members of the ESICM Trials Group Collaborators were not shown in the article but only in the ESM. The full list of collaborators is shown below. The original article has been corrected.

pressure ulcerintensive care
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Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours.

2017

KRAS is one of the most frequently mutated oncogenes in human non-small cell lung cancers (NSCLCs). RAS proteins trigger multiple effector signalling pathways including the highly conserved RAF-MAPK pathway. CRAF, a direct RAS effector protein, is required for KRAS-mediated tumourigenesis. Thus, the molecular mechanisms driving the activation of CRAF are intensively studied. Prohibitin 1 (PHB1) is an evolutionarily conserved adaptor protein and interaction of CRAF with PHB1 at the plasma membrane is essential for CRAF activation. Here, we demonstrate that PHB1 is highly expressed in NSCLC patients and correlates with poor survival. Targeting of PHB1 with two chemical ligands (rocaglamide an…

0301 basic medicineCancer ResearchEGF Family of ProteinsLung NeoplasmsBiologyLigandsProto-Oncogene Proteins p21(ras)03 medical and health scienceschemistry.chemical_compoundMice0302 clinical medicineGrowth factor receptorRocaglamideEpidermal growth factorCarcinoma Non-Small-Cell LungCell Line TumorProhibitinsGeneticsAnimalsHumansMolecular Targeted TherapyProhibitinMolecular BiologyBenzofuransCell ProliferationRas InhibitorMice KnockoutTNF Receptor-Associated Factor 3EffectorXenograft Model Antitumor Assaysrespiratory tract diseasesCell biologyProto-Oncogene Proteins p21(ras)Gene Expression Regulation NeoplasticRepressor Proteins030104 developmental biologychemistry030220 oncology & carcinogenesisras Proteinsraf KinasesSignal transductionSignal TransductionOncogene
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Investigating serendipity in recommender systems based on real user feedback

2018

Over the past several years, research in recommender systems has emphasized the importance of serendipity, but there is still no consensus on the definition of this concept and whether serendipitous items should be recommended is still not a well-addressed question. According to the most common definition, serendipity consists of three components: relevance, novelty and unexpectedness, where each component has multiple variations. In this paper, we looked at eight different definitions of serendipity and asked users how they perceived them in the context of movie recommendations. We surveyed 475 users of the movie recommender system, MovieLens regarding 2146 movies in total and compared tho…

ta113Information retrievalComputer scienceSerendipityuutuudetpalautesuosittelujärjestelmätNoveltyserendipityContext (language use)02 engineering and technologyVariation (game tree)Recommender systemunexpectednessPreferenceMovieLenssattumanovelty020204 information systems0202 electrical engineering electronic engineering information engineering020201 artificial intelligence & image processingRelevance (information retrieval)relevancerecommender systemsProceedings of the 33rd Annual ACM Symposium on Applied Computing
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