0000000000533172
AUTHOR
Qian Zhao
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study (Intensive Care Medicine, (2021), 47, 2, (160-169), 10.1007/s00134-020-06234-9)
The original version of this article unfortunately contained a mistake. The members of the ESICM Trials Group Collaborators were not shown in the article but only in the ESM. The full list of collaborators is shown below. The original article has been corrected.
Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours.
KRAS is one of the most frequently mutated oncogenes in human non-small cell lung cancers (NSCLCs). RAS proteins trigger multiple effector signalling pathways including the highly conserved RAF-MAPK pathway. CRAF, a direct RAS effector protein, is required for KRAS-mediated tumourigenesis. Thus, the molecular mechanisms driving the activation of CRAF are intensively studied. Prohibitin 1 (PHB1) is an evolutionarily conserved adaptor protein and interaction of CRAF with PHB1 at the plasma membrane is essential for CRAF activation. Here, we demonstrate that PHB1 is highly expressed in NSCLC patients and correlates with poor survival. Targeting of PHB1 with two chemical ligands (rocaglamide an…
Investigating serendipity in recommender systems based on real user feedback
Over the past several years, research in recommender systems has emphasized the importance of serendipity, but there is still no consensus on the definition of this concept and whether serendipitous items should be recommended is still not a well-addressed question. According to the most common definition, serendipity consists of three components: relevance, novelty and unexpectedness, where each component has multiple variations. In this paper, we looked at eight different definitions of serendipity and asked users how they perceived them in the context of movie recommendations. We surveyed 475 users of the movie recommender system, MovieLens regarding 2146 movies in total and compared tho…