0000000000534686
AUTHOR
Solomon Derese
showing 15 related works from this author
Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species
2018
A phytochemical investigation of the roots of Aspilia pluriseta led to the isolation of ent-kaurane-type diterpenoids and additional phytochemicals (1⁻23). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the ent-kaurane-type diterpenoids (3⁻6, 6b, 7 and 8) were determined by single crystal X-ray diffraction studies. Eleven of the compounds were also isolated from the roots and the aerial parts of Aspilia mossambicensis. The literature NMR assignments for compounds 1 and 5 were revised. In a cytotoxicity assay, 12α-methoxy-ent-kaur-9(11),1…
Two new flavonoids from Dracaena usambarensis Engl.
2020
Abstract Investigations of the root extract of Dracaena usambarensis Engl. for anticancer principles led to the characterization of one new homoisoflavonoid, (3S)-3,4ʹ,5,6-tetrahydroxy-7-methoxyhomoisoflavanone (1) and a new retrodihydrochalcone, 4ʹ,4-dihydroxy-2,3-dimethoxydihydrochalcone (2) along with six previously reported compounds, including two homoisoflavonoids, 7-O-methyl-8-demethoxy-3-hydroxy-3,9-dihydropunctatin (3) and loureiriol (4); a phenolic amide, 3-(4ʹʹʹ-hydroxyphenyl)-N-[2ʹ-(4ʹʹ-hydroxyphenyl)-2ʹ-methoxyethyl]acrylamide (5); a spirostane, 25S-spirosta-1,4-dien-3-one (6) and two steroids, stigmasterol (7) and stigmasterol 3-O-β-D-glucopyranoside (8). The structures of 1-8…
Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis.
2015
Five new compounds, 4-O-geranylisoliquiritigenin (1), 12-dihydrousararotenoid B (2), 12-dihydrousararotenoid C (3), 4'-O-geranyl-7-hydroxyflavanone (4), and 4'-O-geranyl-7-hydroxydihydroflavanol (5), along with 12 known natural products (6-17) were isolated from the CH2Cl2/MeOH (1:1) extract of the root bark of Millettia usaramensis ssp. usaramensis by chromatographic separation. The purified metabolites were identified by NMR spectroscopic and mass spectrometric analyses, whereas their absolute configurations were established on the basis of chiroptical data and in some cases also by X-ray crystallography. The crude extract was moderately active (IC50 = 11.63 μg/mL) against the ER-negative…
Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
2017
A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A−D (2−5), along with nine known compounds (6−14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 μM, respectively. peerReviewed
CCDC 1409159: Experimental Crystal Structure Determination
2016
Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581
CCDC 1868319: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199
CCDC 1061815: Experimental Crystal Structure Determination
2016
Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581
CCDC 1868324: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199
CCDC 1061111: Experimental Crystal Structure Determination
2017
Related Article: Tsegaye Deyou, Marco Makungu, Matthias Heydenreich, Fangfang Pan, Amra Gruhonjic, Paul A. Fitzpatrick, Andreas Koch, Solomon Derese, Jerry Pelletier, Kari Rissanen, Abiy Yenesew, and Máté Erdélyi|2017|J.Nat.Prod.|80|2060|doi:10.1021/acs.jnatprod.7b00255
CCDC 1868322: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199
CCDC 1868321: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199
CCDC 1868320: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199
CCDC 1409160: Experimental Crystal Structure Determination
2016
Related Article: Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A. Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew|2015|J.Nat.Prod.|78|2932|doi:10.1021/acs.jnatprod.5b00581
CCDC 1868318: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199
CCDC 1868323: Experimental Crystal Structure Determination
2020
Related Article: Souaibou Yaouba, Arto Valkonen, Paolo Coghi, Jiaying Gao, Eric M. Guantai, Solomon Derese, Vincent K. W. Wong, Máté Erdélyi, Abiy Yenesew|2018|Molecules|23|3199|doi:10.3390/molecules23123199