0000000000537301

AUTHOR

Sabrine N.t. Hemmes

showing 3 related works from this author

Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical…

2022

BACKGROUND: High intraoperative PEEP with recruitment manoeuvres may improve perioperative outcomes. We re-examined this question by conducting a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery. METHODS: The three trials enrolled patients at 128 hospitals in 24 countries from February 2011 to February 2018. All patients received volume-controlled ventilation with low tidal volume. Analyses were performed using one-stage, two-level, mixed modelling (site as a random effect; trial as a fixed effect). The primary outcome was a composite of postoperati…

AdultLung Diseases*PEEP*postoperative pulmonary complicationsmechanical ventilationPositive-Pressure RespirationsurgeryAnesthesiology and Pain MedicinePostoperative ComplicationsTidal Volume*surgeryHumanspostoperative pulmonary complicationsPostoperative Period*mechanical ventilationmechanical ventilation; PEEP; postoperative pulmonary complications; surgery; Adult; Humans; Lung; Postoperative Complications; Postoperative Period; Randomized Controlled Trials as Topic; Tidal Volume; Lung Diseases; Positive-Pressure RespirationLungPEEPRandomized Controlled Trials as Topic
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Kinetics of plasma biomarkers of inflammation and lung injury in surgical patients with or without postoperative pulmonary complications

2017

Background Postoperative pulmonary complications (PPCs) are common after major abdominal surgery. The kinetics of plasma biomarkers could improve identification of patients developing PPCs, but the kinetics may depend on intraoperative ventilator settings. Objective To test whether the kinetics of plasma biomarkers are capable of identifying patients who will develop PPCs, and whether the kinetics depend on the intraoperative level of positive end-expiratory pressure (PEEP). Design A preplanned substudy of a randomised controlled trial. Setting Operation room of five centres. Patients Two hundred and forty-two adult patients scheduled for abdominal surgery at risk of developing PPCs. Interv…

AdultMalemedicine.medical_specialtyInflammationLung injuryGastroenterologyArticlelaw.inventionPositive-Pressure Respiration03 medical and health sciencesPostoperative Complications0302 clinical medicineRandomized controlled trial030202 anesthesiologylawInternal medicinemedicineHumansInflammationLungReceiver operating characteristicbusiness.industryLung InjuryAnesthesiology and Pain Medicinemedicine.anatomical_structure030228 respiratory systemAnesthesiaAdult; Biomarkers; Female; Humans; Inflammation; Inflammation Mediators; Lung Injury; Male; Positive-Pressure Respiration; Postoperative Complications; Anesthesiology and Pain MedicineBiomarker (medicine)FemaleInflammation Mediatorsmedicine.symptombusinessBiomarkersAbdominal surgeryBlood samplingEuropean Journal of Anaesthesiology
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Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis

2018

BACKGROUND: Biological phenotypes have been identified within several heterogeneous pulmonary diseases, with potential therapeutic consequences. OBJECTIVE: To assess whether distinct biological phenotypes exist within surgical patients, and whether development of postoperative pulmonary complications (PPCs) and subsequent dependence of intra-operative positive end-expiratory pressure (PEEP) differ between such phenotypes. SETTING: Operating rooms of six hospitals in Europe and USA. DESIGN: Secondary analysis of the 'PROtective Ventilation with HIgh or LOw PEEP' trial. PATIENTS: Adult patients scheduled for abdominal surgery who are at risk of PPCs. INTERVENTIONS: Measurement of pre-operativ…

Lung DiseasesMalemedicine.medical_specialtyInternationalityLung injuryDisease clusterlaw.inventionPositive-Pressure Respiration03 medical and health sciences0302 clinical medicinePostoperative ComplicationsRandomized controlled triallawInternal medicinePreoperative CareMedicineCluster AnalysisHumans030212 general & internal medicineAgedbusiness.industryIncidence (epidemiology)Middle AgedPhenotypePhenotypeAnesthesiology and Pain Medicine030228 respiratory systemBreathingBiomarker (medicine)FemaleInflammation MediatorsbusinessBiomarkersAbdominal surgery
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