0000000000537819

AUTHOR

A. Lenzi

showing 3 related works from this author

Epidemiology of pancreatic neuroendocrine neoplasms. a gender perspective

2020

Purpose: Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating the gender difference in PNEN susceptibility. Thus, the purpose of this study was aimed at examining how gender shapes risk factors, clinicopathological features, and comorbidities in PNENs. Methods: The study design consisted of an Italian multicenter, retrospective study. The study included all consecutive patients with PNENs followed at the participating centers. Two hundred and twenty-nine patients (105 males,124 females, age 54 ± 0.98 years) with PNENs were enrolled at the participating centers. The clinicopathologica…

Malemedicine.medical_specialtyCardiovascular diseases; Epidemiology; Gender; Pancreatic neuroendocrine neoplasms; Sex; Type 2 diabetes; Female; Humans; Male; Middle Aged; Pancreas; Retrospective Studies; Diabetes Mellitus Type 2; Neuroendocrine Tumors; Pancreatic NeoplasmsPancreatic neuroendocrine neoplasmEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismType 2 diabetesDiseaseNeuroendocrine tumorsType 2 diabete03 medical and health sciences0302 clinical medicineEndocrinologyRetrospective StudieInternal medicineDiabetes mellitusEpidemiologymedicinegenderPancreaHumanssexPancreasRetrospective Studiesbusiness.industrypancreatic neuroendocrine neoplasmsRetrospective cohort studyMiddle Agedmedicine.diseaseCardiovascular diseasecardiovascular diseasesNatural historyPancreatic NeoplasmsNeuroendocrine TumorsDiabetes Mellitus Type 2030220 oncology & carcinogenesisPancreatitisFemaleepidemiologytype 2 diabetescardiovascular diseases; epidemiology; gender; pancreatic neuroendocrine neoplasms; sex; type 2 diabetesbusinessNeuroendocrine TumorHuman
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Inquadramento audiologico della tecnopatia da rumore: nuove acquisizioni e prospettive

2004

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GERMLINE PROKINETICIN RECEPTOR 2 (PROKR2) VARIANTS ASSOCIATED WITH CENTRAL HYPOGONADISM CAUSE DIFFERENTAL MODULATION OF DISTINCT INTRACELLULAR PATHWA…

2013

INTRODUCTION: Defects of prokineticin pathway affect the neuroendocrine control of reproduction, but their role in the pathogenesis of central hypogonadism remains undefined, and the functional impact of the missense PROKR2 variants has been incompletely characterized. MATERIAL AND METHODS: In a series of 246 idiopathic central hypogonadism patients, we found three novel (p.V158I, p.V334M, and p.N15TfsX30) and six already known (p.L173R, p.T260M, p.R268C, p.V274D, p.V331M, and p.H20MfsX23) germline variants in the PROKR2 gene. We evaluated the effects of seven missense alterations on two different prokineticin receptor 2 (PROKR2)-dependent pathways: inositol phosphate-Ca(2+) (Gq coupling) a…

MaleKallmann syndromeEndocrinology Diabetes and MetabolismClinical BiochemistryInositol Phosphatemedicine.disease_causeBiochemistryHypogonadotropic hypogonadismGermlineReceptors G-Protein-CoupledCohort StudiesEndocrinologySettore MED/38 - Pediatria Generale E SpecialisticaAdolescent; Adult; Child; Cohort Studies; Cyclic AMP; Female; Genetic Association Studies; Humans; Hypogonadism; Inositol Phosphates; Male; Middle Aged; Mutation Missense; Receptors G-Protein-Coupled; Receptors Peptide; Signal Transduction; Young Adult; Germ-Line MutationReceptorsCyclic AMPmutations; Kallmann syndrome; septo-optic dysplasiaMissense mutationReceptorChildMutationMiddle AgedProkineticinPeptideFemaleHumanSignal TransductionAdultmedicine.medical_specialtyReceptors PeptideAdolescentAdolescent Adult Child Cohort Studies Cyclic AMP; metabolism Female Genetic Association Studies Germ-Line Mutation Humans Hypogonadism; epidemiology/genetics Inositol Phosphates; metabolism Male Middle Aged Missense Receptors; G-Protein-Coupled; genetics Receptors; Peptide; genetics Signal Transduction; genetics Young AdultInositol PhosphatesMutation MissenseGenetic Association StudieBiologyG-Protein-CoupledYoung AdultGermline mutationInternal medicinesepto-optic dysplasiamedicineHumansGenetic Association StudiesGerm-Line MutationHypogonadismBiochemistry (medical)Kallmann syndromeProkineticin receptor 2medicine.diseasePROKR2 hypogonadism prokineticinmutationsAdolescent; Adult; Child; Cohort Studies; Cyclic AMP; Female; Genetic Association Studies; Humans; Hypogonadism; Inositol Phosphates; Male; Middle Aged; Mutation; Missense; Receptors; G-Protein-Coupled; Peptide; Signal Transduction; Young Adult; Germ-Line MutationEndocrinologyMutationCohort StudieMissense
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