0000000000538915

AUTHOR

Wing Tak Wong

showing 3 related works from this author

Frailty and Mortality Outcomes After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

2017

Abstract Background Frailty has been identified as a risk factor for mortality. However, whether frailty increases mortality risk in patients undergoing percutaneous coronary intervention (PCI) has been controversial. Therefore, we conducted a systematic review and meta-analysis of the frailty measures and mortality outcomes in this setting. Methods PubMed and EMBASE were searched until July 23, 2017 for studies evaluating the association between frailty measures and mortality in individuals who have undergone PCI. Results A total of 141 entries were retrieved from our search strategy. A total of 8 studies involving 2332 patients were included in the final meta-analysis (mean age: 69 years;…

Malemedicine.medical_specialtymedicine.medical_treatmentSubgroup analysisCoronary Artery Disease030204 cardiovascular system & hematologyCoronary AngiographyRisk Assessment03 medical and health sciences0302 clinical medicinePercutaneous Coronary InterventionPredictive Value of TestsInternal medicineCause of DeathmedicineHumans030212 general & internal medicineRisk factorGeneral NursingAgedProportional Hazards ModelsFrailtybusiness.industryHealth PolicyMortality rateHazard ratioPercutaneous coronary interventionGeneral MedicineMiddle Agedmedicine.diseasePrognosisSurvival AnalysisConfidence intervalTreatment OutcomeMeta-analysisConventional PCIMultivariate AnalysisFemaleMedical emergencyGeriatrics and GerontologybusinessJournal of the American Medical Directors Association
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Cancer antigen-125 and risk of atrial fibrillation: a systematic review and meta-analysis

2017

WOS: 000458034100002

medicine.medical_specialtybusiness.industryCancerAtrial fibrillation030204 cardiovascular system & hematologymedicine.diseaseMean differenceCancer antigen03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisMeta-analysisInternal medicineJournal ArticleMedicineSinus rhythmIn patientCardiology and Cardiovascular MedicineProspective cohort studybusinessOriginal ResearchHeart Asia
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AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats

2011

BACKGROUND AND PURPOSE Nitric oxide (NO) plays an important role in endothelial function, and impaired NO production is involved in hypertension. Therefore, compounds that regulate endothelial NO synthase (eNOS) may be of therapeutic benefit. A novel, low molecular weight compound AVE3085 is a recently developed compound with the ability to enhance eNOS transcription. The present study investigated the effects of AVE3085 in endothelial dysfunction associated with hypertension. EXPERIMENTAL APPROACH Spontaneously hypertensive rats (SHRs) were treated with AVE 3085 (10 mg·kg·day−1, orally) for 4 weeks. Isometric force measurement was performed on rings of isolated aortae in organ baths. Prote…

Pharmacologymedicine.medical_specialtybiologyEndotheliumNitrotyrosineNitric Oxide Synthase Type IIIbiology.organism_classificationmedicine.diseaseNitric oxideNitric oxide synthasechemistry.chemical_compoundEndocrinologymedicine.anatomical_structureBlood pressurechemistryEnosInternal medicinemedicinebiology.proteinEndothelial dysfunctionBritish Journal of Pharmacology
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