Polyaspartamide-g-Polylactide graft cpolymers able to form nanoparticles obtained by a novel synthetic strategy.

A Par j1/Par J2-polymeric nanoaggragates as a new tool for allergy vaccination

Nanoparticulate Systems for Drug Delivery and Targeting to the Central Nervous System

Brain delivery is one of the major challenges for the neuropharmaceutical industry since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the central nervous system (CNS) because of the existence of a physiological low permeable barrier, the blood-brain barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. Many recent data demonstrate that drugs could be transported successfully into the brain using colloidal systems after i.v. injection by several mechanisms such as endocytosis or P-glycoprotei…

Development of nimesulide loaded solid lipid nanoparticles.

THERAPEUTIC-LOADED LIPID NANOSTRUCTURES AND BRAIN DISEASES.

Central Nervous System (CNS) diseases represent the largest and fastest growing area of unmet medical need since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the CNS because of the existence of a physiological low permeable barrier, the Blood-Brain Barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. In particular, in this chapter, the most recent data demonstrating the potential of lipid nanostructures, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), to tra…

ALTERNATIVE MATERIALS FOR PROTECTING CU- AND AG-BASED ARCHAEOLOGICAL ARTEFACTS

CATIONIC SLN AS TARGETING DRUG DELIVERY SYSTEMS

Nanoscience and nanotechnology have received much attention in the last decade and they actually form one of the most important fields of technology and innovation. Due to rapid progresses in nanotechnology and biotechnology, nanoparticles have come to be seen as a viable vehicle for the delivery and release of drugs and nucleic acids. Within this field, the use of solid lipid nanoparticles (SLNs) is of particular importance. In particular, cationic SLN are promising non-viral gene delivery carriers suitable for systemic and topic administration. The surface of these nanoparticles is positively charged and the negatively charged nucleic acids are complexed to the their surface. The obtained…

NANOPARTICELLE POLIMERICHE OTTENUTE DA NUOVI COPOLIMERI DI UNA POLIASPARTAMIDE

Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

Background: In hepatocellular carcinoma (HCC), different signaling pathways are de-regulated, and among them, the expression of the epidermal growth factor receptor (EGFR). Tyrphostin AG-1478 is a lipophilic low molecular weight inhibitor of EGFR, preferentially acting on liver tumor cells. In order to overcome its poor drug solubility and thus improving its anticancer activity, it was entrapped into nanostructured lipid carriers (NLC) by using safe ingredients for parenteral delivery. Results: Nanostructured lipid carriers (NLC) carrying tyrphostin AG-1478 were prepared by using the nanoprecipitation method and different matrix compositions. The best system in terms of mean size, PDI, zeta…

Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

DNA PLASMID DELIVERY INTO HEPATOCELLULAR CARCINOMA CELLS BY COMPLEXATION WITH SOLID LIPID NANOPARTICLES

PREPARATION AND CHARACTERIZATION OF GALACTOSILATED NANODEVICES CONTAINING A RIBAVIRIN PRODRUG FOR LIVER TARGETING.

Nanoassemblies of Amphiphilic Cyclodextrin and Tributyltin(IV)Complexes of meso-Tetra (4-sulfonatophenyl)porphine: Spectroscopy, Release and Cytotoxicity on Human Melanoma Cells

Large-scale Radiation Manufacturing of Hierarchically Assembled Nanogels

Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, represent a niche in the development of “smart” nanoparticles for drug delivery and diagnostics. They offer unique advantages over other systems, including a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap active metal or mineral cores for imaging or phototherapeutic purposes; stimuli-responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive and robust preparation methodologies is at the ba…

ENTRAPMENT OF TYRPHOSTIN AG 14-78 INTO LIPID NANOPARTICLES IMPROVES ITS ANTITUMOR ACTIVITY AGAINST HUMAN HEPATOCARCINOMA CELLS

CATIONIC SLN AS TARGETING GENE DELIVERY SYSTEMS FOR HEPATOCELLULAR CARCINOMA

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related deaths. In the United States, the incidence of HCC has almost tripled during the past two decades and HCC has become one of the fastest growing cancers. While surgical removal of tumor tissues is an effective approach to protect relatively healthy liver tissue, it is only applicable to a small subset of HCC patients with specific pathological conditions, such as confined tumor mass without portal hypertension. Therefore, there is an urgent need to develop novel therapeutic strategies to treat this deadly disease. Systemic tumor-targeted gene delivery is attracting increasin…

Silibilina per il trattamento delle patologie oculari neurodegenerative e formulazioni comprendenti nanostrutture per la sua veicolazione

Par j 1/Par j 2-nanoaggregati: un nuovo strumento per la terapia antiallergica

POLYMERIC MICELLES AS DRUG DELIVERY SYSTEMS TOWARDS BRAIN TARGETING

Galactose-decorated polymeric nanoparticles based on a polyaspartamide

Encapsulation of sorafenib into lipid nanoparticles improves its antitumor activity.

Effects of kind and amount of surfactants on physical-chemical properties of cationic solid lipid nanoparticles (SLN) for the treatment of hepatocellular carcinoma.

Lipid nanocarrier for the treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the sixth most prevalent cancer and the third most frequent cause of cancer-related death. Unlike most solid tumors the incidence and mortality of HCC have increased in the United States and Europe in the past decade. Most patients are diagnosed at advanced stages, so there is an urgent need for new systemic therapies [1,2]. To improve the delivery of therapeutic agents to tumor cells in vivo it’s necessary to overcome several problems, such as drug resistance at the tumor level due to physiological barriers (non cellular based mechanism), drug resistance at the cellular level (cellular mechanism), drug distribution, biotransformation and clearance of antic…