0000000000543937

AUTHOR

Eduard Gallardo

showing 5 related works from this author

Clinical characteristics and outcomes of thymoma-associated myasthenia gravis

2021

[Background and purpose] Prognosis of myasthenia gravis (MG) in patients with thymoma is not well established. Moreover, it is not clear whether thymoma recurrence or unresectable lesions entail a worse prognosis of MG.

medicine.medical_specialtyThymomaThymomaEnfermedad del sistema nerviosoMiastenia gravischemical and pharmacologic phenomenaGastroenterology03 medical and health sciences0302 clinical medicineDisease severityRecurrenceInternal medicinehemic and lymphatic diseasesMyasthenia GravismedicineHumansIn patient030212 general & internal medicineneoplasmsNeurologíaMyasthenia gravisRetrospective Studiesbusiness.industryHazard ratioOdds ratioThymus Neoplasmsthymomamedicine.diseaseThymectomyPrognosisConfidence intervalMyasthenia gravisThymomEfectos fisiológicossurgical procedures operativeNeurologyMulticenter studySignos y síntomasNeurology (clinical)Neoplasm Recurrence LocalbusinessTimoma030217 neurology & neurosurgery
researchProduct

Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome

2022

[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.

Maleprogressive multifocal leukoencepdiarrheacholinergic receptorplasma exchangemiddle agedadultimmunologic factornauseaanemiahypertrichosisageddrug withdrawaldiabetes mellitusdisease severityTRIALsafetycorticosteroidhypertensionImmunologyMiastenia gravismethotrexateArticlebulbar paralysispancytopeniaMuscular DiseasescompulsionMyasthenia Gravischolinesterase inhibitorcross-sectional studyHumansImmunologic FactorshumanRITUXIMABarthralgiaNeurologíaMalalties muscularsAgedRetrospective Studiesmyasthenia gravisleukopeniaabdominal painDrug testingmajor clinical studyCross-Sectional StudiesDrug side effectscyclophosphamideobservational studyNeurology (clinical)immunoglobulinFEATURESefficacyclinical outcomeelectrophysiological procedurescomputer assisted tomographyDOUBLE-BLINDTratamiento médicorituximabOutcome Assessment Health CareImmunologiamuscle specific tyrosine kinaseRegistriestacrolimusazathioprineMedicamentoGeneral Neurosciencenephrotoxicitygeneral condition deteriorationhyperplasiatrialMiddle Agedliver toxicitydrug toxicityunclassified drugfemaleEfectes secundaris dels medicamentsSAFETYFemaledouble-blindheadacheblindnessAdultAssaigs clínics de medicamentsmalefeaturesfollow uppneumoniacyclosporinemycophenolate mofetilprotein tyrosine kinaseimmunosuppressive agentallergyalopeciaEFFICACYclinical featureosteopeniaSpainprednisonehyperglycemiaautoantibodyFollow-Up Studies
researchProduct

Absence of dysferlin alters myogenin expression and delays human muscle differentiation 'in vitro'

2006

Mutations in dysferlin cause a type of muscular dystrophy known as dysferlinopathy. Dysferlin may be involved in muscle repair and differentiation. We compared normal human skeletal muscle cultures expressing dysferlin with muscle cultures from dysferlinopathy patients. We quantified the fusion index of myoblasts as a measure of muscle development and conducted optic and electronic microscopy, immunofluorescence, Western blot, flow cytometry, and real-time PCR at different developmental stages. Short interference RNA was used to corroborate the results obtained in dysferlin-deficient cultures. A luciferase reporter assay was performed to study myogenin activity in dysferlin-deficient cultur…

MaleDysferlinopathyMuscle ProteinsIn Vitro TechniquesBiochemistryMuscular DystrophiesDysferlinmedicineMyocyteHumansMuscular dystrophyMuscle SkeletalMolecular BiologyDysferlinMyogeninCells CulturedbiologyMyogenesisMusclesSkeletal muscleMembrane ProteinsCell DifferentiationCell Biologymedicine.diseaseMolecular biologyCD56 Antigenmedicine.anatomical_structureGene Expression RegulationCase-Control Studiesbiology.proteinFemaleMyogeninMyofibrilSignal Transduction
researchProduct

Clinical and therapeutic features of myasthenia gravis in adults based on age at onset

2020

[Objective] To describe the characteristics of patients with very-late-onset myasthenia gravis (MG).

AdultMalePediatricsmedicine.medical_specialtyThymomagenetic structuresCross-sectional studyInvestigación médicaEnfermedad del sistema nerviosoMEDLINEMiastenia gravisLate onsetDISEASECLASSIFICATIONArticleACETYLCHOLINE-RECEPTOR03 medical and health sciences0302 clinical medicineimmune system diseasesMyasthenia GravismedicineEnfermedades neuromuscularesHumansRITUXIMAB030212 general & internal medicineAge of OnsetAgedbusiness.industryAnálisis de datosMiddle Agedmedicine.diseaseMyasthenia gravisnervous system diseasesCross-Sectional StudiesTreatment OutcomeMulticenter studyANTIBODIESAUTOANTIBODIESFemaleObservational studyNeurology (clinical)Age of onsetbusiness030217 neurology & neurosurgeryMUSK
researchProduct

Transcriptome Analysis of Ullrich Congenital Muscular Dystrophy Fibroblasts Reveals a Disease Extracellular Matrix Signature and Key Molecular Regula…

2015

Background Collagen VI related myopathies encompass a range of phenotypes with involvement of skeletal muscle, skin and other connective tissues. They represent a severe and relatively common form of congenital disease for which there is no treatment. Collagen VI in skeletal muscle and skin is produced by fibroblasts. Aims & Methods In order to gain insight into the consequences of collagen VI mutations and identify key disease pathways we performed global gene expression analysis of dermal fibroblasts from patients with Ullrich Congenital Muscular Dystrophy with and without vitamin C treatment. The expression data were integrated using a range of systems biology tools. Results were validat…

Pathologymedicine.medical_specialtyUllrich congenital muscular dystrophyIntegrin alpha3Integrinlcsh:MedicineDown-RegulationAscorbic AcidBiologyMuscular DystrophiesExtracellular matrixLamininCollagen VImedicineCell AdhesionHumansGene Regulatory NetworksMuscular dystrophylcsh:ScienceWound HealingMultidisciplinarySclerosisGene Expression Profilinglcsh:RFibroblastsmedicine.diseaseMolecular biologyExtracellular MatrixUp-RegulationGene expression profilingMicroRNAsbiology.proteinlcsh:QWound healingResearch ArticleSignal Transduction
researchProduct