0000000000547530
AUTHOR
R. Poli
Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes
Background Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Methods A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici D…
TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)
ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…
CCDC 116646: Experimental Crystal Structure Determination
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CCDC 250351: Experimental Crystal Structure Determination
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CCDC 162296: Experimental Crystal Structure Determination
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CCDC 162295: Experimental Crystal Structure Determination
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CCDC 243377: Experimental Crystal Structure Determination
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CCDC 191763: Experimental Crystal Structure Determination
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CCDC 624422: Experimental Crystal Structure Determination
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CCDC 180477: Experimental Crystal Structure Determination
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CCDC 144916: Experimental Crystal Structure Determination
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CCDC 178174: Experimental Crystal Structure Determination
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CCDC 144917: Experimental Crystal Structure Determination
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CCDC 231765: Experimental Crystal Structure Determination
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CCDC 164809: Experimental Crystal Structure Determination
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CCDC 189193: Experimental Crystal Structure Determination
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CCDC 209632: Experimental Crystal Structure Determination
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CCDC 233004: Experimental Crystal Structure Determination
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CCDC 116645: Experimental Crystal Structure Determination
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CCDC 271274: Experimental Crystal Structure Determination
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CCDC 116644: Experimental Crystal Structure Determination
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CCDC 156596: Experimental Crystal Structure Determination
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CCDC 191764: Experimental Crystal Structure Determination
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CCDC 633154: Experimental Crystal Structure Determination
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CCDC 258376: Experimental Crystal Structure Determination
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CCDC 258377: Experimental Crystal Structure Determination
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CCDC 209633: Experimental Crystal Structure Determination
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CCDC 148635: Experimental Crystal Structure Determination
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CCDC 271277: Experimental Crystal Structure Determination
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CCDC 633155: Experimental Crystal Structure Determination
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CCDC 164163: Experimental Crystal Structure Determination
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CCDC 148636: Experimental Crystal Structure Determination
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CCDC 156595: Experimental Crystal Structure Determination
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CCDC 191762: Experimental Crystal Structure Determination
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CCDC 231951: Experimental Crystal Structure Determination
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CCDC 132464: Experimental Crystal Structure Determination
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CCDC 206713: Experimental Crystal Structure Determination
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CCDC 271276: Experimental Crystal Structure Determination
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CCDC 178173: Experimental Crystal Structure Determination
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CCDC 159215: Experimental Crystal Structure Determination
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CCDC 156594: Experimental Crystal Structure Determination
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CCDC 218899: Experimental Crystal Structure Determination
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CCDC 132771: Experimental Crystal Structure Determination
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CCDC 156597: Experimental Crystal Structure Determination
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CCDC 164810: Experimental Crystal Structure Determination
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CCDC 178376: Experimental Crystal Structure Determination
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