0000000000547632

AUTHOR

Y. Ezoe

showing 2 related works from this author

TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)

2012

ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…

medicine.medical_specialtyGastrointestinal tumorsPerformance statusbusiness.industryHematologySevere hypoxiaNeutropeniamedicine.diseaseRashGastroenterologyDiscontinuationNon colorectalOncologyInternal medicineToxicitymedicinemedicine.symptombusinessAnnals of Oncology
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ORIGIN: metal creation and evolution from the cosmic dawn

2012

Herder, Jan-Willem den et al.

HOT INTERGALACTIC MEDIUMUNIVERSEChemical evolutionMission7. Clean energy01 natural sciencesSpectral lineSettore FIS/05 - Astronomia E Astrofisica010303 astronomy & astrophysicsmedia_commonPhysicsHigh Energy Astrophysical Phenomena (astro-ph.HE)NUCLEOSYNTHESISCOSMIC cancer databaseClusters of galaxiesSatellite MissionEpoch (reference date)Astrophysics::Instrumentation and Methods for AstrophysicsFORESTGALAXIESGamma-ray burstsAstrophysics - Instrumentation and Methods for AstrophysicsAstrophysics - High Energy Astrophysical PhenomenaX-ray Mission Gamma-ray bursts Clusters of galaxies Warm-hot intergalactic medium Chemical evolutionWarm-hot intergalactic mediumAstrophysics - Cosmology and Nongalactic AstrophysicsAstrophysics and AstronomyStructure formationCosmology and Nongalactic Astrophysics (astro-ph.CO)Clusters of galaxiemedia_common.quotation_subjectAstrophysics::High Energy Astrophysical PhenomenaREDSHIFTFOS: Physical sciencesAstrophysics::Cosmology and Extragalactic AstrophysicsX-ray Mission Gamma-ray bursts Clusters of galaxies Warm-hot intergalactic medium Chemical evolutionABSORPTION-SPECTRA010309 opticsX-rayYIELDS0103 physical sciencesGamma-ray burstInstrumentation and Methods for Astrophysics (astro-ph.IM)X-ray; Mission; Gamma-ray bursts; Clusters of galaxies; Warm-hot intergalactic medium; Chemical evolutionAstronomyAstronomy and AstrophysicsRedshiftGalaxyUniverse13. Climate actionChemical evolution; Clusters of galaxies; Gamma-ray bursts; Mission; Warm-hot intergalactic medium; X-ray; Astronomy and Astrophysics; Space and Planetary ScienceSpace and Planetary ScienceGamma-ray burstCLUSTERSExperimental Astronomy
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