0000000000548297

AUTHOR

Veronika Grau

showing 3 related works from this author

Trägt leukozytäres Acetylcholin zur chronischen Abstoßung von Nierentransplantaten bei?

2010

Einleitung: Akute Abstoßungsepisoden prädisponieren für die chronische Abstoßung von Nierentransplantaten. Für die fatale akute Abstoßung haben wir experimentell gezeigt, dass Monozyten, die sich in Transplantatgefäßen massiv ansammeln, Acetylcholin (ACh) produzieren.[for full text, please go to the a.m. URL]

Pathologymedicine.medical_specialtyAllogeneic transplantationbusiness.industryIsograft610 Medical sciences; MedicineCholine acetyltransferaseBlotCholine transporterPathogenesissurgical procedures operativeddc: 610MedicineImmunohistochemistrybusinessAcetylcholinemedicine.drug
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Administration of keratinocyte growth factor down-regulates the pulmonary capacity of acetylcholine production.

2007

Abstract Keratinocyte growth factor protects the lung against various injurious stimuli. The protective mechanisms, however, are not yet fully understood. The aim of this study is to determine the influence of keratinocyte growth factor on the pulmonary capacity to synthesize acetylcholine, a potent regulator of pulmonary functions which is potentially involved in lung damage. Rats were treated twice (days 1 and 2) intratracheally with keratinocyte growth factor and analyzed at day 4. The mRNA expression of choline acetyltransferase – the acetylcholine synthesizing enzyme – was analyzed by real-time RT-PCR in the lung and in isolated alveolar epithelial type II cells. Choline acetyltransfer…

Malemedicine.medical_specialtyFibroblast Growth Factor 7CellDown-RegulationBiologyBiochemistryCholine O-Acetyltransferasechemistry.chemical_compoundInternal medicinemedicineAnimalsRNA MessengerCation Transport ProteinsLungSurfactant homeostasisLungEpithelial CellsPulmonary SurfactantsCell BiologyCholine acetyltransferaseAcetylcholineRecombinant ProteinsRatsCholine transporterEndocrinologymedicine.anatomical_structurechemistryRats Inbred LewKeratinocyte growth factorKeratinocyteAcetylcholinemedicine.drugThe international journal of biochemistrycell biology
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Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection…

2009

Abstract A new role and source of the old mediator acetylcholine is described, which is produced by graft monocytes and attenuates monocytic ATP-signaling. During acute rejection, large numbers of leukocytes accumulate in the blood vessels of experimental renal allografts. About 70% of them are activated, cytotoxic monocytes that appear to be involved in allograft destruction. ACh exerts anti-inflammatory effects upon monocytes/macrophages and has been proposed to be a key player in neuroimmunological interactions. Its short half-life, however, makes it unlikely that neuronal ACh affects blood leukocytes. Renal transplantation was performed in the allogeneic DA to LEW and in the isogeneic L…

Graft RejectionPathologymedicine.medical_specialtyIsograftImmunologyBiologyReceptors NicotinicParacrine signallingAdenosine TriphosphateIn vivoParacrine CommunicationmedicineImmunology and AllergyCytotoxic T cellAnimalsTransplantation HomologousLymphocytesCation Transport ProteinsMonocyteCell BiologyKidney TransplantationAcetylcholineRatsUp-RegulationTransplantationTransplantation Isogeneicmedicine.anatomical_structureRats Inbred LewImmunohistochemistryCholinergicSignal TransductionJournal of leukocyte biology
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