0000000000548676

AUTHOR

Mohit Prasad

showing 2 related works from this author

A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster

2004

We have examined the process by which cell diversity is generated in neuroblast (NB) lineages in the central nervous system of Drosophila melanogaster. Thoracic NB6-4 (NB6-4t) generates both neurons and glial cells, whereas NB6-4a generates only glial cells in abdominal segments. This is attributed to an asymmetric first division of NB6-4t, localizing prospero (pros) and glial cell missing (gcm) only to the glial precursor cell, and a symmetric division of NB6-4a, where both daughter cells express pros and gcm. Here we show that the NB6-4t lineage represents the ground state, which does not require the input of any homeotic gene, whereas the NB6-4a lineage is specified by the homeotic genes…

Central Nervous SystemCyclin ELineage (genetic)Cell divisionDown-RegulationNerve Tissue ProteinsCell fate determinationNeuroblastCyclin EAnimalsDrosophila ProteinsCell LineageHomeodomain ProteinsNeuronsbiologyStem CellsNeuropeptidesGenes HomeoboxGene Expression Regulation DevelopmentalNuclear ProteinsCell DifferentiationCell BiologyCell cyclebiology.organism_classificationGanglia InvertebrateCell biologyDNA-Binding ProteinsDrosophila melanogasterTrans-ActivatorsDrosophila melanogasterHomeotic geneNeurogliaTranscription FactorsNature Cell Biology
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Cyclin E acts under the control of Hox-genes as a cell fate determinant in the developing central nervous system.

2005

The mechanisms controlling the generation of cell diversity in the central nervous system belong to the major unsolved problems in developmental biology. The fly Drosophila melanogaster is a suitable model system to examine these mechanisms at the level of individually identifiable cells. Recently, we have provided evidence that CyclinE--largely independent of its role in cell proliferation--plays a critical role in the specification of neural stem cells (neuroblasts). CycE specifies neuronal fate within neuroblast lineages by acting upstream of glial factors (prospero and glial cell missing), whereby levels of CycE are controlled by homeotic genes, the master control genes regulating segme…

Central Nervous SystemCell fate determinationBiologyModels BiologicalNeuroblastCyclin EAnimalsHumansCell LineageHox geneMolecular BiologyGeneticsNeuronsStem CellsGenes HomeoboxGene Expression Regulation DevelopmentalCell Biologybiology.organism_classificationNeural stem cellCell biologyDrosophila melanogasterStem cellDrosophila melanogasterHomeotic geneDevelopmental biologyDevelopmental BiologyCell cycle (Georgetown, Tex.)
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