0000000000550143

AUTHOR

Inmaculada Galan-chilet

showing 4 related works from this author

Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain.

2018

Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1,451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric…

0301 basic medicineinorganic chemicalsAdultMaleRiskDiabetes riskHealth Toxicology and MutagenesisPopulationPhysiologychemistry.chemical_elementUrine010501 environmental sciencesToxicology01 natural sciencesArsenicalsArticleArsenic03 medical and health scienceschemistry.chemical_compoundYoung AdultDiabetes mellitusDiabetes MellitusOdds RatioPrevalenceMedicineHumanseducationArsenic0105 earth and related environmental scienceseducation.field_of_studyintegumentary systembusiness.industryConfoundingGeneral MedicineOdds ratioEnvironmental ExposureMiddle Agedmedicine.diseasePollution030104 developmental biologychemistrySeafoodSpainEnvironmental PollutantsFemaleArsenobetainebusinessEnvironmental pollution (Barking, Essex : 1987)
researchProduct

Polymorphisms in endothelin system genes, arsenic levels and obesity risk.

2015

Background/objectivesObesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system has been related to endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (EDNRA) activates lipolysis in adipocytes, the two endothelin receptors mediate arsenic-stimulated adipocyte dysfunction, and endothelin system can regulate adiposity by modulating adiponectin activity in different situations and, therefore, influence obesity development. The aim of the present study was to analyze if single nucleotide polymorphisms (SNPs) in the EDN system could be associated with human obesity.Subjects/methodsWe analyz…

MaleEspañaObesidad:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Fat Distribution::Adiposity [Medical Subject Headings]Endothelins:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Endothelins [Medical Subject Headings]Polymorphism (computer science)Risk Factors:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Elements::Arsenic [Medical Subject Headings]:Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings]education.field_of_studyMultidisciplinary:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]Genètica humanaEndothelinsQRMiddle AgedPrognosisReceptor Endothelin APolimorfismo de nucleótido único:Anatomy::Cells::Connective Tissue Cells::Adipocytes [Medical Subject Headings]ObesitatMedicineFemaleTomografía computarizada por rayos X:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]Endothelin receptor:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Image Interpretation Computer-Assisted::Tomography X-Ray Computed [Medical Subject Headings]Research Articlemedicine.hormonemedicine.medical_specialtyGenotype:Phenomena and Processes::Mathematical Concepts::Probability::Risk [Medical Subject Headings]SciencePopulationSingle-nucleotide polymorphism:Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipolysis [Medical Subject Headings]BiologyPolymorphism Single NucleotideArsenicReceptores de endotelinasInternal medicineAdipocitos:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Membrane Proteins::Receptors Cell Surface::Receptors Peptide::Receptors Endothelin [Medical Subject Headings]medicineHumansGenetic Predisposition to DiseaseObesityeducation:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic::Polymorphism Single Nucleotide [Medical Subject Headings]AdiponectinHaplotypeEnfermedad crónicamedicine.diseaseObesityEndocrinologyHaplotypesSpain:Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Adipokines::Adiponectin [Medical Subject Headings]GenotipoFollow-Up StudiesArsénicoPLoS ONE
researchProduct

Plasma selenium levels and oxidative stress biomarkers: a gene-environment interaction population-based study.

2014

The role of selenium exposure in preventing chronic disease is controversial, especially in selenium-repleted populations. At high concentrations, selenium exposure may increase oxidative stress. Studies evaluating the interaction of genetic variation in genes involved in oxidative stress pathways and selenium are scarce. We evaluated the cross-sectional association of plasma selenium concentrations with oxidative stress levels, measured as oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8-oxo-7,8-dihydroguanine (8-oxo-dG) in urine, and the interacting role of genetic variation in oxidative stress candidate genes, in a representative sample of 1445 men and women…

inorganic chemicalsAdultMalemedicine.medical_specialtyCandidate geneAdolescentGenotypechemistry.chemical_elementUrinemedicine.disease_causeBiochemistrychemistry.chemical_compoundSeleniumYoung AdultPhysiology (medical)Internal medicineMalondialdehydemedicineHumansGene–environment interactionAgedGlutathione DisulfideChemistryfood and beveragesDeoxyguanosineGlutathioneMiddle AgedMalondialdehydeGlutathioneOxidative StressEndocrinologyCross-Sectional StudiesBiochemistry8-Hydroxy-2'-DeoxyguanosineSpainBiomarker (medicine)FemaleGene-Environment InteractionOxidative stressSeleniumBiomarkersFree radical biologymedicine
researchProduct

Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study

2019

Introduction: Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. Objectives: We evaluated the cross-sectional association of urinary metal and metal mixtures with urinary oxidative stress biomarkers, including oxidized to reduced glutathione ratio (GSSG/GSH), malondialdehyde (MDA), and 8‑oxo‑7,8‑dihydroguanine (8-oxo-dG), in a representative sample of a general population from Spain (Hortega Study). Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured by ICPMS in 1440 Hortega Study participants. Results: The geomet…

AdultMaleUrine metals010504 meteorology & atmospheric sciencesPopulationchemistry.chemical_elementUrineZinc010501 environmental sciencesPopulation-basedmedicine.disease_cause01 natural scienceschemistry.chemical_compoundChromiumMetal mixturesMalondialdehydeMetals HeavymedicineHumanseducationlcsh:Environmental sciences0105 earth and related environmental sciencesGeneral Environmental ScienceAgedlcsh:GE1-350Cadmiumeducation.field_of_studyDeoxyguanosineGlutathioneMiddle AgedMalondialdehydeGlutathioneCross-Sectional Studieschemistry8-Hydroxy-2'-DeoxyguanosineSpainOxidative stressEnvironmental PollutantsFemaleOxidative stressBiomarkersNuclear chemistryEnvironment International
researchProduct