0000000000553828
AUTHOR
M. Cocchi
Probiotics, prebiotics and symbiotics in inflammatory bowel diseases: state-of-the-art and new insights
Inflammatory bowel disease (IBD) consists of two distinct clinical forms, ulcerative colitis (UC) and Crohn's disease (CD), with unknown aetiology, which nevertheless are considered to share almost identical pathophysiological backgrounds. Up to date, a full coherent mechanistic explanation for IBD is still lacking, but people start to realize that the pathogenesis of IBD involves four fundamental components: the environment, gut microbiota, the immune system and the genome. As a consequence, IBD development might be due to an altered immune response and a disrupted mechanism of host tolerance to the non-pathogenic resident microbiota, leading to an elevated inflammatory response. Consideri…
Lactobacillus casei and Bifidobacterium lactis supplementation reduces tissue damage of intestinal mucosa and liver after 2,4,6-trinitrobenzenesulfonic acid treatment in mice
Probiotics (PB) are living microorganisms that act as a commensal population in normal intestines and confer numerous beneficial effects on the host. The introduction of probiotics in the treatment of inflammatory bowel disease (IBD) prolongs remission. The aim of this study was to investigate the intestinal and hepatic effects of PB supplementation in an experimental IBD model in mice induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). In the first step of the experimental procedure, CD-1 male mice, 5 to 6 weeks old, were randomly divided into 3 groups and inoculated intrarectally with, respectively, saline, alcohol, or TNBS to assess the experimental IBD model. In the second step, mice…
ORIGIN: metal creation and evolution from the cosmic dawn
Herder, Jan-Willem den et al.
New insights on the puzzling LMXB 1RXS J180408.9-342058: the intermediate state, the clocked type-I X-ray bursts and much more
1RXS J180408.9--342058 is a low mass X-ray binary hosting a neutron star, which shows X-ray activity at very different mass-accretion regimes, from very faint to almost the Eddington luminosity. In this work, we present a comprehensive X-ray study of this source using data from the Neil Gehrels Swift Observatory, NuSTAR and INTEGRAL/JEM-X. In order to follow the spectral evolution, we analysed the 2015 outburst using Swift data and three Nustar observations. Besides the canonical hard and soft spectral states, we identified the rarely observed intermediate state. This was witnessed by the appeareance of the accretion disk emission in the spectrum (at $kT_{\rm disk}$ $\sim$0.7 keV) and the s…