0000000000555510

AUTHOR

Alejandro Herreros Pomares

showing 2 related works from this author

P1.05-013 Lung Tumorspheres as a Platform for Testing New Therapeutic Strategies in Non-Small Cell Lung Cancer

2017

Pulmonary and Respiratory MedicineOncologymedicine.medical_specialtyLungbusiness.industryTranslational researchmedicine.diseasemedicine.anatomical_structureOncologyInternal medicineMedicineNon small cellbusinessLung cancerJournal of Thoracic Oncology
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Abstract 3056: Lung tumor spheres as in vitro platform for testing new therapeutic strategies against cancer stem cells

2018

Abstract Background: Treatment resistance is related to cancer stem cells (CSCs), a highly tumorigenic subpopulation of cells capable of growing and forming tumor spheres under non-adherent conditions. This study aimed to isolate and characterise CSCs from resected non-small cell lung cancer (NSCLC) patients' tumor-tissue and cell lines like tumor spheres and to use them as an in vitro platform for drug screening. Methods: The study was performed on tumour cells from 8 resected NSCLC patients and 12 NSCLC cell lines grown in monolayer and as spheres. The expression of 60 genes, including CSC-markers, pluripotency inducers, cell cycle regulators and components of the Notch, Wnt and Hedgehog …

Homeobox protein NANOGCancer ResearchOncologybiologySOX2KLF4Cancer stem cellCellular differentiationCD44Cancer researchbiology.proteinCytotoxic T cellCD90Cancer Research
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