0000000000560051

AUTHOR

Stefan Krebs

0000-0002-2213-8575

showing 3 related works from this author

Kulturen des Reparierens

2018

Reparieren und Instandhalten sind ökonomisch wie kulturell zentrale Praktiken im »Leben« technischer Dinge und Infrastrukturen. Der Band rückt diese bislang wenig untersuchten Tätigkeiten in den Vordergrund und fragt nach den Wissensformen der unterschiedlichen Kulturen des Reparierens. Die Expertisen und politischen Ambitionen menschlicher Akteure finden dabei ebenso Berücksichtigung wie die Eigendynamik der Dinge. Die Beiträge untersuchen Praktiken wie die Uhr- oder Computerreparatur sowie Räume wie die Wohnung und das Krankenhaus, das Repair Café und die Stadt des Globalen Südens. Nicht zuletzt geht es um die Frage, inwiefern Reparieren und reparaturfreundliches Design zu mehr Nachhaltig…

Civil societyCulture theoryPolitical scienceSustainabilityCultural studiesHistory of technologySocial scienceConsumption (sociology)
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Kulturen des Reparierens und die Lebensdauer der Dinge

2018

AnthropologyPolitical scienceCultural studiesHistory of technology
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Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

2016

The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were essential for the generation of pathogenic TH17 cells. Using their IL-6 receptor α-chain (IL-6Rα), Sirpα+ DCs trans-presented IL-6 to T cells during the process of cognate interaction. While ambient IL-6 was sufficient to suppress the induction of expression of the transcription factor Foxp3 in T cells, trans-presentation of IL-6 by DC-bound IL-6Rα (called 'IL-6 cluster signaling'…

0301 basic medicineCell typebiologyCellular differentiationImmunologyLymphocyte differentiationFOXP3Priming (immunology)medicine.disease_cause3. Good healthCell biologyAutoimmunity03 medical and health sciences030104 developmental biology0302 clinical medicineImmunologybiology.proteinmedicineImmunology and AllergyInterleukin 6Transcription factor030215 immunologyNature Immunology
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