0000000000568148

AUTHOR

A. Craxã¬

showing 2 related works from this author

Premature ovarian senescence and a high miscarriage rate impair fertility in women with HCV

2017

Background & Aims Premenopausal women who are HCV positive (HCV+) have failing ovarian function, which is likely to impact their fertility. Thus, we investigated the reproductive history, risk of infertility, and pregnancy outcomes in women of childbearing age who were HCV+. Methods Three different groups were studied: (1) Clinical cohort: 100 women who were HCV+ and also had chronic liver disease (CLD), age matched with 50 women who were HBV+ with CLD and with 100 healthy women; all women were consecutively observed in three gastroenterology units in hospitals in Italy; (2) 1,998 women who were HCV+ and enrolled in the Italian Platform for the Study of Viral Hepatitis Therapies (PITER)…

Anti-Mullerian hormone; Antiviral therapy; HBV; HCV; Sustained viral response; HepatologyInfertilitymedicine.medical_specialtySustained viral responsemedia_common.quotation_subjectFertilityAnti-Müllerian hormoneAntiviral therapyMiscarriage03 medical and health sciences0302 clinical medicineHBVMedicineProspective cohort studymedia_commonGynecologyAnti-Müllerian hormone Antiviral therapy HBV HCV Sustained viral response030219 obstetrics & reproductive medicineHepatologybusiness.industryObstetricsAnti-Müllerian hormone; Antiviral therapy; HBV; HCV; Sustained viral responseAnti-Mullerian hormonemedicine.diseaseAnti-Müllerian hormoneGestational diabetesCohortHCV030211 gastroenterology & hepatologyAnti-Müllerian hormone; Antiviral therapy; HBV; HCV; Sustained viral response; HepatologybusinessLive birthCell aging
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Is early recurrence of hepatocellular carcinoma in HCV cirrhotic patients affected by treatment with direct-acting antivirals? A prospective multicen…

2017

SummaryBackground Data on HCV-related hepatocellular carcinoma (HCC) early recurrence in patients whose HCC was previously cured, and subsequently treated by direct-acting antivirals (DAAs), are equivocal. Aim To assess the risk of HCC early recurrence after DAAs exposure in a large prospective cohort of HCV-cirrhotic patients with previous successfully treated HCC, also looking for risk factors for cancer early recurrence. Methods We enrolled 143 consecutive patients with complete response after curative treatment of HCC, subsequently treated with DAAs and monitored by the web-based RESIST-HCV database. Clinical, biological, and virological data were collected. The primary endpoint was the…

Liver CirrhosisMalemedicine.medical_specialtyCarcinoma HepatocellularSettore MED/09 - Medicina InternaEarly RecurrenceDIRECT ACTING ANTIVIRALSAntiviral AgentsGastroenterologyhepatocellular carcinoma (HCC)03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicinemedicineClinical endpointCarcinomaHumansPharmacology (medical)Prospective StudiesProspective cohort studyneoplasmsComplete responseAgedhepatocellular carcinoma (HCC) HCV directacting antivirals (DAAs)Settore MED/12 - GastroenterologiaSettore MED/08 - ANATOMIA PATOLOGICAHepatologybusiness.industrydirectacting antivirals (DAAs)Liver NeoplasmsCarcinomaGastroenterologyCancerHepatocellularMiddle Agedmedicine.diseaseHepatitis Cdigestive system diseasesNeoplasm RecurrenceLocal030220 oncology & carcinogenesisHepatocellular carcinomaHCVCatheter AblationFemale030211 gastroenterology & hepatologyNeoplasm Recurrence Localbusiness
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