Author: Nigel Junior Belshaw

0000000000568212

AUTHOR

Nigel Junior Belshaw

showing 1 related works from this author

Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme E…

2015

<b><i>Background:</i></b> Recently, we have shown anti-proliferative and pro-apoptotic effects of indicaxanthin associated with epigenetic modulation of the onco-suppressor <i>p16</i><sup><i>INK4a</i></sup> in the human colon cancer cell line CACO2. In the present study, the epigenetic activity of indicaxanthin and the mechanisms involved were further investigated in other colorectal cancer cell lines. <b><i>Methods:</i></b> LOVO1, CACO2, HT29, HCT116, and DLD1 cells were used to evaluate the potential influence of consistent dietary concentrations of indicaxanthin on DNA methylation, and the epigenetic mech…

PyridinesColorectal cancerMedicine (miscellaneous)BiologyDNA methyltransferaseEpigenesis Geneticchemistry.chemical_compoundCell Line TumorSettore BIO/10 - BiochimicaGeneticsmedicineHumansEpigeneticsCell Proliferationchemistry.chemical_classificationCell growthColorectal cancer Chemoprevention Phytochemicals Indicaxanthin Epigenetics DNA methyltransferase Molecular modeling BetalainsDNA Methylationmedicine.diseaseSettore CHIM/08 - Chimica FarmaceuticaBetaxanthinsSettore BIO/18 - GeneticaEnzymePhytochemicalchemistryColonic NeoplasmsDNA methylationCancer researchIndicaxanthinFood Science

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
  - PE2_2 Phenomenology of fundamental interactions
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  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
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  - PE2_14Lasers, ultra-short lasers and laser physics
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  - PE2_13Quantum optics and quantum information
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- PE1Mathematics
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LSLife Sciences
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SHSocial Sciences and Humanities
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