0000000000583553

AUTHOR

Cindy Tissier

showing 2 related works from this author

Spontaneous splenic rupture after thrombolysis for ischemic stroke.

2015

Spontaneous spleen rupture with no recent report of trauma is an extremely rare and life-threatening cause of intraperitoneal hemorrhage.We present the first case of an atraumatic pathological splenic rupture following alteplase thrombolysis for ischemic stroke.

Malemedicine.medical_specialtymedicine.medical_treatmentSpleen ruptureTissue plasminogen activatorFibrinolytic AgentsInternal medicinemedicineHumansThrombolytic TherapyPathologicalStrokeThrombectomyRupture Spontaneousbusiness.industryGeneral MedicineThrombolysisSplenic RuptureMiddle Agedmedicine.diseaseStrokeTissue Plasminogen ActivatorIschemic strokeEmergency MedicineCardiologybusinessFibrinolytic agentmedicine.drugThe American journal of emergency medicine
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Physiological and metabolic actions of mycophenolate mofetil on cultured newborn rat cardiomyocytes in normoxia and in simulated ischemia

2004

Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work was thus to evaluate the effects of MMF on isolated cardiomyocytes (CM) in normal conditions and in an in vitro model of simulated ischemia (SI; substrate-free hypoxia) and reperfusion (R; reoxygenation). Myocyte-enriched cultures were prepared from newborn rat heart ventricles. The transmembrane potentials were recorded using conventional microelectrodes and the cell contracti…

Adenosinemedicine.medical_treatmentMyocardial IschemiaIschemiaMyocardial ReperfusionPharmacologyMycophenolateXanthineMembrane Potentialschemistry.chemical_compoundmedicineAnimalsMyocytes CardiacPharmacology (medical)Rats WistarCells CulturedHypoxanthinePharmacologyHeart transplantationHypoxanthineMycophenolic AcidHypoxia (medical)medicine.diseaseXanthineCell HypoxiaRatsElectrophysiologyImmunosuppressive drugAnimals NewbornchemistryAnesthesiamedicine.symptomImmunosuppressive AgentsFundamental and Clinical Pharmacology
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