0000000000584413
AUTHOR
Roberta Montalbano
Polymerase Chain Reaction (PCR)
The mechanism by which histone deacetylase inhibitors sensitize hepatoma and colon cancer cells to TRAIL-induced apoptosis
Parthenolide sensitizes human hepatocarcinoma cells to TRAIL-induced apoptosis
IL PARTENOLIDE SENSIBILIZZA CELLULE DI EPATOCARCINOMA UMANO ALL' APOPTOSI INDOTTA DA TRAIL
Tumor models: in vivo applications
Synergistic interaction between Parthenolide and TRAIL induces apoptosis in human hepatocarcinoma cells.
Partenolide, a natural compound used in traditional medicine for its anti-inflammatory activity, has recently shown anti-tumor and apoptotic effects. Our studies demonstrated that HepG2; Hep3B and SK-Hep1 hepatocarcinoma cells, which are resistant to human recombinant TRAIL, are potently sensitized to TRAIL-induced apoptosis by low doses of parthenolide resulting in a marked synergist effect. To clarify the mechanism that accounts for this interaction, we demonstrated that parthenolide/TRAIL combination markedly increased DR4 and DR5. These effects might be correlated with STAT proteins modifications. In fact parthenolide and parthenolide/TRAIL combination decreased STAT3 and STAT5 and thei…