0000000000585437
AUTHOR
Torsten Behrendt
Synthesis of 2,3‐Dihydro‐4‐pyridones, 4‐Quinolones, and 2,3‐Dihydro‐4‐azocinones by Visible‐Light Photocatalytic Aerobic Dehydrogenation
Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones
Through variation of our previously published total synthesis of two highly active anti-inflammatory macrolactones from the oxacyclododecindione family (J. Tauber, M. Rohr, T. Walter, G. Erkel and T. Opatz, Org. Biomol. Chem., 2015, 13, 7813-7821), seven new representatives of this compound class were prepared. Substitution of the 14-hydroxy group in oxacyclododecindione with a methyl substituent provided a readily accessible non-natural analogue which has similar pharmacological properties to the scarcely available natural product. Since the producible amount of substance is therefore no longer restricted by low fermentation yields, extensive in vivo studies become possible for the first t…
CCDC 1998325: Experimental Crystal Structure Determination
Related Article: Carina Weber, Nina Vierengel, Thorsten Walter, Torsten Behrendt, Tobias Lucas, Gerhard Erkel, Till Opatz|2020|Org.Biomol.Chem.|18|5906|doi:10.1039/D0OB00958J
CCDC 1998326: Experimental Crystal Structure Determination
Related Article: Carina Weber, Nina Vierengel, Thorsten Walter, Torsten Behrendt, Tobias Lucas, Gerhard Erkel, Till Opatz|2020|Org.Biomol.Chem.|18|5906|doi:10.1039/D0OB00958J
CCDC 1998324: Experimental Crystal Structure Determination
Related Article: Carina Weber, Nina Vierengel, Thorsten Walter, Torsten Behrendt, Tobias Lucas, Gerhard Erkel, Till Opatz|2020|Org.Biomol.Chem.|18|5906|doi:10.1039/D0OB00958J