0000000000585437

AUTHOR

Torsten Behrendt

showing 5 related works from this author

Synthesis of 2,3‐Dihydro‐4‐pyridones, 4‐Quinolones, and 2,3‐Dihydro‐4‐azocinones by Visible‐Light Photocatalytic Aerobic Dehydrogenation

2019

Green chemistryChemistryOrganic Chemistry4-quinolonesPhotocatalysisDehydrogenationPhysical and Theoretical ChemistryVisible light photocatalyticPhotochemistryEuropean Journal of Organic Chemistry
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Total synthesis and biological evaluation of seven new anti-inflammatory oxacyclododecindione-type macrolactones

2020

Through variation of our previously published total synthesis of two highly active anti-inflammatory macrolactones from the oxacyclododecindione family (J. Tauber, M. Rohr, T. Walter, G. Erkel and T. Opatz, Org. Biomol. Chem., 2015, 13, 7813-7821), seven new representatives of this compound class were prepared. Substitution of the 14-hydroxy group in oxacyclododecindione with a methyl substituent provided a readily accessible non-natural analogue which has similar pharmacological properties to the scarcely available natural product. Since the producible amount of substance is therefore no longer restricted by low fermentation yields, extensive in vivo studies become possible for the first t…

Macrocyclic CompoundsNatural productStereochemistryOrganic ChemistrySubstituentTotal synthesisBiochemistrychemistry.chemical_compoundchemistryIn vivoSide chainBioassayFermentationPhysical and Theoretical ChemistryIC50Organic & Biomolecular Chemistry
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CCDC 1998325: Experimental Crystal Structure Determination

2020

Related Article: Carina Weber, Nina Vierengel, Thorsten Walter, Torsten Behrendt, Tobias Lucas, Gerhard Erkel, Till Opatz|2020|Org.Biomol.Chem.|18|5906|doi:10.1039/D0OB00958J

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(E)-14-chloro-1113-dihydroxy-4559-tetramethyl-4567-tetrahydro-2H-benzo[d][1]oxacyclododecine-210(1H)-dioneExperimental 3D Coordinates
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CCDC 1998326: Experimental Crystal Structure Determination

2020

Related Article: Carina Weber, Nina Vierengel, Thorsten Walter, Torsten Behrendt, Tobias Lucas, Gerhard Erkel, Till Opatz|2020|Org.Biomol.Chem.|18|5906|doi:10.1039/D0OB00958J

(E)-1113-bis(benzyloxy)-9-ethyl-455-trimethyl-4567-tetrahydro-2H-benzo[d][1]oxacyclododecine-210(1H)-dioneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1998324: Experimental Crystal Structure Determination

2020

Related Article: Carina Weber, Nina Vierengel, Thorsten Walter, Torsten Behrendt, Tobias Lucas, Gerhard Erkel, Till Opatz|2020|Org.Biomol.Chem.|18|5906|doi:10.1039/D0OB00958J

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(E)-1113-bis(benzyloxy)-4559-tetramethyl-4567-tetrahydro-2H-benzo[d][1]oxacyclododecine-210(1H)-dione unknown solvateExperimental 3D Coordinates
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