0000000000585964
AUTHOR
Bernhard Maisch
showing 2 related works from this author
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
2011
Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurrence risk. So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide association study (GWAS) to identify loci contributing to sporadic DCM.One thousand one hundred and seventy-nine DCM patients and 1108 controls contributed to the discovery phase. Pools of DNA stratified on disease status, population, age, and gender were constituted and used for testing association of DCM with 517 382 single nucleotide polymorphisms (SNPs). Three DCM-associated SNPs were confirmed by individual genotyping (P5.0 10(-7)), and two of them, rs10927875 and rs2234962, were replicated in ind…
Prävention von Vorhofarrhythmien durch Overdrive-Stimulation und Automatische Ruhefrequenz — Die PROVE-Studie
2000
Im Rahmen der PROVE-Studie werden Patienten mit klas-sischer Schrittmacherindikation bzgl. atrialer Arrhythmien untersucht. Patienten mit und ohne Vorhofarrhythmien werden in verschiedene Subgruppen unterteilt. In der Gruppe mit atrialen Arrhythmien zeigen die bisherigen Daten einen praventiven antiarrhythmischen Effekt der Overdrive — Stimulation in Kombination mit der Automatischen Ruhefrequenz