Author: Sara Ghezzal

0000000000585991

AUTHOR

Sara Ghezzal

showing 1 related works from this author

Cholesterol trafficking and raft-like membrane domain composition mediate scavenger receptor class B type 1-dependent lipid sensing in intestinal epi…

2018

IF 5.547; International audience; Scavenger receptor Class B type 1 (SR-B1) is a lipid transporter and sensor. In intestinal epithelial cells, SR-B1-dependent lipid sensing is associated with SR-B1 recruitment in raft-like/ detergent-resistant membrane domains and interaction of its C-terminal transmembrane domain with plasma membrane cholesterol. To clarify the initiating events occurring during lipid sensing by SR-B1, we analyzed cholesterol trafficking and raft-like domain composition in intestinal epithelial cells expressing wild-type SR-B1 or the mutated form SR-B1-Q445A, defective in membrane cholesterol binding and signal initiation. These features of SR-B1 were found to influence bo…

0301 basic medicineArticlescavenger receptor03 medical and health scienceschemistry.chemical_compoundMembrane MicrodomainsLipid droplet[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyHumans[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyScavenger receptorIntestinal MucosaMolecular BiologyLipid raft[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyCholesterolcholesterolEpithelial CellsCell BiologyLipid DropletsScavenger Receptors Class BSphingolipidCell biologySphingomyelinslipid raftTransmembrane domain030104 developmental biologychemistrylipid traffickinglipids (amino acids peptides and proteins)sphingolipidSignal transductionCaco-2 CellsLysophospholipidsSphingomyelinSignal Transduction

researchProduct

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
  - PE2_8Gas and plasma physics
  - PE2_5Classical and quantum physics of gravitational interactions
  - PE2_7Nuclear and particle astrophysics
  - PE2_9 Electromagnetism
  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
  - PE2_14Lasers, ultra-short lasers and laser physics
  - PE2_17Metrology and measurement
  - PE2_16Non-linear physics
  - PE2_12Optics, non-linear optics and nano-optics
  - PE2_13Quantum optics and quantum information
  - PE2_15Thermodynamics
- PE1Mathematics
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  - PE1_6Geometry and global analysis
  - PE1_8Analysis
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  - PE11_12Semi-conducting and magnetic materials engineering
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  - PE11_14Computational methods for materials engineering
LSLife Sciences
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- LS2Integrative Biology: from Genes and Genomes to Systems
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  - LS4_1Organ and tissue physiology and pathophysiology
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SHSocial Sciences and Humanities
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