Author: L. D'onofrio

0000000000586522

AUTHOR

L. D'onofrio

Efficacy and safety of Everolimus and Exemestane in hormone-receptor positive (HR+) human-epidermal-growth-factor negative (HER2−) advanced breast cancer patients: New insights beyond clinical trials. The EVA study

Abstract Background The BOLERO-2 trial reported efficacy and safety of Everolimus (EVE) and Exemestane (EXE) combination in HR+ advanced breast cancer (ABC) patients. The BALLET trial further evaluated the safety of EVE-EXE in HR+ ABC patients, without reporting efficacy data. Aim of the EVA real-life study was to collect data of efficacy and safety of EVE-EXE combination in the clinical setting, as well as exploring efficacy according to EVE Dose-Intensity (DI) and to previous treatment with Fulvestrant. Patients and methods This study aimed to describe the outcome of ABC pts treated with EVE-EXE combination in terms of median duration of EVE treatment and ORR in a real-life setting. Resul…

research product

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3a

Abbott, R., et al. (LIGO and VIRGO Collaboration)

research product

PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_3Experimental particle physics with accelerators
  - PE2_4Experimental particle physics without accelerators
  - PE2_6Nuclear, hadron and heavy ion physics
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  - PE2_7Nuclear and particle astrophysics
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  - PE2_10Atomic, molecular physics
  - PE2_11Ultra-cold atoms and molecules
  - PE2_18Equilibrium and non-equilibrium statistical mechanics: steady states and dynamics
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  - PE2_13Quantum optics and quantum information
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- PE1Mathematics
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  - PE1_13Probability
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  - PE1_4 Algebraic and complex geometry
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  - PE3_1Structure of solids, material growth and characterisation
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  - PE11_2Engineering of metals and alloys
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  - PE11_6Engineering of carbon materials
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  - PE11_12Semi-conducting and magnetic materials engineering
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  - PE11_14Computational methods for materials engineering
LSLife Sciences
- LS1Molecules of Life: Biological Mechanisms, Structures and Functions
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  - LS1_1Macromolecular complexes including interactions involving nucleic acids, proteins, lipids and carbohydrates
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  - LS1_12Protein design
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  - LS1_14Innovative methods and modelling in molecular, structural and synthetic biology
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  - LS1_7Molecular biophysics, biomechanics, bioenergetics
- LS2Integrative Biology: from Genes and Genomes to Systems
  - LS2_1Genetics
  - LS2_3Epigenetics
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  - LS4_1Organ and tissue physiology and pathophysiology
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  - LS4_3Physiology of ageing
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  - LS4_5Non-hormonal mechanisms of inter-organ and tissue communication
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  - LS3_9Cell differentiation, formation of tissues and organs
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  - LS3_3Cell behaviour, including control of cell shape, cell migration
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  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
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SHSocial Sciences and Humanities
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