Author: Jarkko Valjakka

0000000000586623

AUTHOR

Jarkko Valjakka

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Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues.

2009

An active local renin-angiotensin system (RAS) has recently been found in the human eye. The aim of the present study was to compare the activities of central RAS enzymes (ACE1 and 2) in porcine ocular tissues, morphologically and physiologically close to the human eye. In addition, the effects of three ACE-inhibitory tripeptides on these enzymes were evaluated.Enucleated fresh porcine eyes were used. Activities of ACE1 and ACE2 and their inhibition by bioactive tripeptides (Ile-Pro-Pro, Val-Pro-Pro, Leu-Pro-Pro) as well as by a standard ACE-inhibitor captopril were assayed in the vitreous body, the retina and the ciliary body using fluorometric detection methods.Activity of ACE1 as well as…

medicine.medical_specialtyCaptoprilgenetic structuresSwinePeptideAngiotensin-Converting Enzyme InhibitorsTripeptideBiologyIn Vitro TechniquesPeptidyl-Dipeptidase ARetina03 medical and health sciences0302 clinical medicineCiliary bodyInternal medicineRenin–angiotensin systemmedicineAnimalsPharmacology (medical)030304 developmental biologyPharmacologychemistry.chemical_classification0303 health sciencesOligopeptideRetinaCiliary Bodyeye diseases3. Good healthVitreous BodyOphthalmologyEnzymeEndocrinologymedicine.anatomical_structurechemistryAngiotensin-converting enzyme 2030221 ophthalmology & optometrysense organsAngiotensin-Converting Enzyme 2OligopeptidesJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

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