The effects of three remineralizing agents on regression of white spot lesions in children: A two-week, single-blind, randomized clinical trial.

Background This study investigated the effect of three remineralizing agents on improving white spot lesions (WSLs). Material and Methods This clinical trial included children who had at least one WSL on anterior teeth of upper or lower jaws. The participants were randomly assigned to 4 groups by treatment: 1) a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); 2) a cream containing hydroxyapatite and fluoride (Remin Pro); 3) a 2% sodium fluoride gel; and 4) usual home care (control). The treatment was performed for 3 times over 10 days using special trays for retaining remineralizing agents. The area and mineral content of WSLs were measured a…