0000000000587005

AUTHOR

Paula Suárez-pinilla

showing 5 related works from this author

Predictors of clinical remission following a first episode of non-affective psychosis: Sociodemographics, premorbid and clinical variables

2012

The aim of the study was to identify predictors associated with a lower likelihood of achieving a clinical remission 1 year after the first break of the illness. Participants were 174 consecutive subjects included in a first episode programme with no prior treatment with antipsychotic medication. Patients were assigned to haloperidol, olanzapine or risperidone in a randomized, open-label, prospective clinical trial. The main outcome variable was the remission criteria developed by the Remission in Schizophrenia Working Group. Clinical variables were included in a logistic regression analysis in order to predict the remission state at 1 year. At 1 year, 31% of patients met criteria for remis…

AdultMaleOlanzapinePediatricsmedicine.medical_specialtymedicine.medical_treatmentLogistic regressionSeverity of Illness IndexTime-to-TreatmentBenzodiazepinesYoung AdultRisk FactorsmedicineHumansLongitudinal StudiesAntipsychoticPsychiatryBiological PsychiatryFirst episodeRisperidoneRemission InductionPrognosisRisperidonemedicine.diseaseClinical trialPsychiatry and Mental healthLogistic ModelsPsychotic DisordersOlanzapineSchizophreniadupSchizophreniaEducational StatusHaloperidolFemaleSchizophrenic PsychologyPsychologyAntipsychotic Agentsmedicine.drugPsychiatry Research
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Childhood trauma and substance use underlying psychosis: a systematic review

2020

[EN] Background: Schizophrenia spectrum disorders (SSD) are mental diseases caused by a combination of genetic susceptibility and a number of environmental factors. Among these factors, the role of traumatic events suffered in childhood, as well as that of substance use, have been of particular research interest. Objectives: To conduct a systematic review to clarify whether there is an interaction between childhood trauma and substance use related to the diagnosis or symptoms of SSD. It was also the objective of this review to collate the associations that may exist between the three variables of the study (trauma, substance use and psychosis). Methods: We conducted a systematic search resu…

PsychosisSubstances useRC435-571Poison controlEsquizofreniaReview Article药物滥用Cannabis useSuicide preventionOccupational safety and healthChildhood traumaConsumo de cannabis思觉失调Injury preventionmedicinePsicosisPsychiatryWindow of opportunitybusiness.industryHuman factors and ergonomicsConsumo de sustanciasmedicine.diseasePsychosis• Schizophrenia is caused by a combination of genetic susceptibility and a number of environmental factors. Traumatic events suffered in childhood as well as substance use have been of particular interest.• Our results reveal a positive association between traumatic experiences in childhood and drug use and their interaction with schizophrenia spectrum disorders.• Detecting cases of childhood trauma as well as cases of trauma associated with substance use could be useful for the primary prevention of some psychiatric diseases such as psychosis.大麻使用精神分裂症SchizophreniaTrauma infantilSchizophreniabusiness童年创伤Clinical psychology
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Prediction of acute clinical response following a first episode of non affective psychosis: results of a cohort of 375 patients from the Spanish PAFI…

2013

Abstract Objective Predicting response to antipsychotic treatment might optimize treatment strategies in early phases of schizophrenia. We aimed to investigate sociodemographic, premorbid and clinical predictors of response to antipsychotic treatment after a first episode of non-affective psychosis. Method 375 (216 males) patients with a diagnosis of non affective psychosis entered the study. The main outcome measure was clinical response at 6 weeks and variables at baseline were evaluated as predictors of response. ANOVA for continuous and chi-square for categorical data were used to compare responders and non-responders. Multivariate logistic regression was used to establish a prediction …

AdultMalePsychosismedicine.medical_specialtyAdolescentLogistic regressionCohort StudiesYoung AdultPredictive Value of TestsOutcome Assessment Health CaremedicineHumansFamily historyPsychiatryBiological PsychiatryRetrospective StudiesPharmacologyFirst episodePsychiatric Status Rating ScalesAnalysis of VarianceChi-Square DistributionMiddle Agedmedicine.diseaseLogistic ModelsPsychotic DisordersSchizophreniaSpainCohortdupFemalePsychologyDiagnosis of schizophreniaAntipsychotic AgentsProgress in neuro-psychopharmacologybiological psychiatry
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Comparison of metabolic effects of aripiprazole, quetiapine and ziprasidone after 12 weeks of treatment in first treated episode of psychosis.

2013

This randomized open-label study compared the incidence of metabolic side effects of aripiprazole, ziprasidone and quetiapine in a population of medication-naive first-episode psychosis patients. A total of 202 subjects were enrolled. Body weight, body mass index, leptin, fasting lipids and fasting glycaemic parameters were measured at baseline and at 3 months follow-up. A hundred and sixty-six patients completed the follow-up and were included in the analyses. A high proportion of patients experienced a significant weight increase (>7% of their baseline weight): 23% ziprasidone (n=12), 32% with quetiapine (n=16) and 45% with aripiprazole (n=31). Patients treated with aripiprazole gained si…

AdultMalemedicine.medical_specialtyPsychosisDibenzothiazepinesPopulationAripiprazoleQuinolonesWeight GainGastroenterologyPiperazinesQuetiapine FumarateSex FactorsInternal medicinemedicineHumansZiprasidoneeducationPsychiatryBiological Psychiatryeducation.field_of_studybusiness.industryLeptinmedicine.diseaseProlactinPsychiatry and Mental healthThiazolesCholesterolPsychotic DisordersQuetiapineAripiprazoleFemalemedicine.symptombusinessWeight gainBody mass indexmedicine.drugAntipsychotic AgentsFollow-Up StudiesSchizophrenia research
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Differential associations of cognitive insight components with pretreatment characteristics in first-episode psychosis

2014

An increasing number of studies have focused on cognitive insight (i.e. awareness of one's own thinking) in psychotic disorders. However, little is known about the premorbid and pretreatment correlates of cognitive insight in the early course of psychosis. One hundred and three patients experiencing first-episode psychosis (FEP) were assessed shortly after treatment initiation for cognitive insight. Pretreatment and baseline clinical, functional and neurocognitive characteristics were examined. The self-reflectiveness dimension of cognitive insight was independently associated with clinical insight and executive functioning, whereas self-certainty was associated with premorbid IQ, premorbid…

AdultMalemedicine.medical_specialtyPsychosisMetacognitionNeuropsychological TestsExecutive FunctionYoung AdultCognitionmedicineHumansYoung adultPsychiatryBiological PsychiatryCognitionAwarenessmedicine.diseaseExplained variationSelf ConceptPsychiatry and Mental healthCross-Sectional StudiesPsychotic DisordersSchizophreniaFemaleVerbal memoryPsychologySocial AdjustmentNeurocognitiveClinical psychologyPsychiatry Research
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