Early results of the LHCf experiment and their contribution to ultra-high-energy cosmic ray physics

LHCf is an experiment dedicated to the measurement of neutral particles emitted in the very forward region of LHC collisions. The physics goal is to provide data for calibrating hadron interaction models that are used in the study of Extremely High-Energy Cosmic-Rays. The LHCf experiment acquired data from April to July 2010 during commissioning time of LHC operations at low luminosity. Production spectra of photons and neutrons emitted in the very forward region ($��>$ 8.4) have been obtained. In this paper preliminary results of the photon spectra taken at $\sqrt{s}$ = 7TeV are reported.

O1‐06‐07: Misprocessing of Multiple Transmembrane Substrates Reveals Gamma‐Secretase Dysfunction in Both Familial and Sporadic Alzheimer's Diseases

Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction.

Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins, designated Alc(alpha), Alc(beta), and Alc(gamma). The Alcs express in neurons dominantly and largely colocalize with the Alzheimer amyloid precursor protein (APP) in the brain. Alcs and APP show an identical function as a cargo receptor of kinesin-1. Moreover, proteolytic processing of Alc proteins appears highly similar to that of APP. We found that APP alpha-secretases ADAM 10 and ADAM 17 primarily cleave Alc proteins and trigger the subsequent secondary intramembranous cleavage of Alc C-terminal fragments by a presenilin-dependent gamma-secretase complex, thereby generating "APP p3-like" and non-aggregative Alc pe…