0000000000588828
AUTHOR
F Brighina
Spontaneous intracranial hypotension in a patient with meningeal diverticula: a case report
Objective: spontaneous intracranial hypotension (SIH) can sometime represent a puzzling clinical condition due to missing causal factors and poor response to treatment. Here we describe a SIH case where cerebrospinal fluid (CSF) leaks follow to the uncommon cause of meningeal diverticula[1]. Materials: a 54-years-old-woman who works as a caregiver came to our attention for a symptomatology characterized by heavy headache localized on the vertex that started after long lasting upright position and that improved with rest. During last two months the pain has begun costant, associated with vertigo and non responsive to rest or symptomatic drugs. Methods: the patient was admitted to our Unit an…
Aortic pulse wave velocity in children with migraine: a case control study
Background: Migraine has been associated with increased risk of cardiovascular (CV) accident like angina and myocardial infarction(1) . Vascular changes in migraineur traditionally may prevail in cranial blood district, but more likely it is a generalized vascular phenomenon.(2) Previous studies showed an increased aortic pulse wave velocity (aPWV), a direct measure of aortic stiffness and an independent predictor of stroke and CV disease, in young and middle-aged migraineurs(3) Here we hypothesized that, if associated with the pathogenetic bases of the disease, increased aPWV should be appreciable also in migraineurs children. Materials and Methods: : We studied 10 children with migraine w…
Application of tRNS to improve Multiple Sclerosis Fatigue: a sham-controlled study
Background and aims: Fatigue is one of the most common, early, and disabling symptom in Multiple Sclerosis (MS). tDCS on Dorso-Lateral Prefrontal Cortex seems to give positive results on MS fatigue. Recently, a new stimulation protocol, transcranial Random Noise Stimulation (tRNS), showed powerful facilitatory effects on motor cortex in healthy subjects and ameliorated pain in MS patients. Here we aimed to explore effects of motor cortex tRNS in MS fatigue.Methods: 13 MS fatigued patients were enrolled in a blind, sham controlled tRNS study. 7 patients received 1.5 mA, 101-640 Hz tRNS stimulation and 6 patient received sham stimulation, both stimulations applied daily over M1 for 15 minutes…
Clinical effects of different montages of Transcranial Direct Current Stimulation (tDCS) in patients with Parkinson’s Disease
Background: Parkinson’s disease (PD) is characterized by motor deficits which may not completely respond to the dopaminergic therapy, thus posing a therapeutic challenge. Non-invasive brain stimulation techniques such as transcranial direct current stimulation (tDCS) have shown promising results as possible alternative of treatment in different neurological disorders including PD. The therapeutic effect of tDCS, which may increase (anodal currents) or decrease (cathodal currents) the cortical excitability level, likely relies on modulation of cortico-subcortical interactions and abnormal patterns of cortical activation. Objective: To investigate safety and therapeutic potential of different…