Evaluation of new functional pasta using TOPSIS methodology

Nowadays several studies are focused on the introduction of Opuntia in frequently consumed foods, such as pasta and bakery products. Food products containing Opuntia are in fact able to reduce body weight and plasma LDL cholesterol, lipids and glucose. Foods, that may provide health and wellness benefits, are known as "functional foods". The aim of this paper is the evaluation of a new functional pasta comprising Opuntia able to guarantee health benefits without altering the organoleptic properties of the final product. For this purpose, a set of samples, based on different concentration of Opuntia solution and process parameters, was prepared for the production of short and long pasta. The…

Uno strumento per la valutazione multicriterio dei progetti in ambito F.S.E.

Supplementary Material for: First-Line Immune Checkpoint Inhibitor-Based Sequential Therapies for Advanced Hepatocellular Carcinoma: Rationale for Future Trials

Introduction: Atezolizumab (ATEZO) plus bevacizumab (BEVA) represents the new standard of care for the treatment of advanced hepatocellular carcinoma (HCC). However, the choice of the second-line treatment after the failure of immunotherapy-based first-line remains elusive. Taking into account the weaknesses of the available evidence, we developed a simulation model based on available phase III randomized clinical trials (RCTs) to identify optimal risk/benefit sequential strategies. Methods: A Markov model was built to estimate the overall survival (OS) of sequential first- and second-line systemic treatments. Sequences starting with first-line ATEZO plus BEVA followed by 5 second-line trea…