0000000000589176

AUTHOR

M. Falcone

showing 6 related works from this author

Outcomes of patients hospitalized with community-acquired, health care-associated, and hospital-acquired pneumonia

2009

Background: Traditionally, pneumonia has been classified as either community- or hospital-acquired. Although only limited data are available, health care-associated pneumonia has been recently proposed as a new category of respiratory infection. ``Health care associated pneumonia{'' refers to pneumonia in patients who have recently been hospitalized, had hemodialysis, or received intravenous chemotherapy or reside in a nursing home or long-term care facility. Objective: To ascertain the epidemiology and outcome of community-acquired, health care-associated, and hospital-acquired pneumonia in adults hospitalized in internal medicine wards. Design: Multicenter, prospective observational study…

Settore MED/09 - Medicina InternaPneumonia
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[Rt or RDt, that is the question!]

2021

The article compares two of the most followed indices in the monitoring of COVID-19 epidemic cases: the Rt and the RDt indices. The first was disseminated by the Italian National Institute of Health (ISS) and the second, which is more usable due to the lower difficulty of calculation and the availability of data, was adopted by various regional and local institutions. The rationale for the Rt index refers to that for the R0 index, the basic reproduction number, which is used by infectivologists as a measure of contagiousness of a given infectious agent in a completely susceptible population. The RDt index, on the other hand, is borrowed from the techniques of time series analysis for the tr…

RiskTime FactorsSARS-CoV-2monitoring indexesHealth PolicyIncidenceDecision MakingBasic Reproduction NumberCOVID-19COVID-19; epidemic development; monitoring indexes; swab outcome date; symptoms onset date; COVID-19; Decision Making; Health Policy; Humans; Incidence; Italy; Nasopharynx; Risk; SARS-CoV-2; Symptom Assessment; Time Factors; Basic Reproduction Number; Epidemiological Monitoring; PandemicsItalyNasopharynxEpidemiological Monitoringepidemic developmentHumansswab outcome dateCOVID-19 swab outcome date symptoms onset date monitoring indexes epidemic developmentSymptom AssessmentPandemicssymptoms onset dateEpidemiologia e prevenzione
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Prophylaxis of venous thromboembolism in elderly patients with multimorbidity

2013

none 327 si Pharmacological thromboprophylaxis (TP) is known to reduce venous thromboembolism (VTE) in medical inpatients, but the criteria for risk-driven prescription, safety and impact on mortality are still debated. We analyze data on elderly patients with multimorbidities admitted in the year 2010 to the Italian internal medicine wards participating in the REPOSI registry to investigate the rate of TP during the hospital stay, and analyze the factors that are related to its prescription. Multivariate logistic regression, area under the ROC curve and CART analysis were performed to look for independent predictors of TP prescription. Association between TP and VTE, bleeding and death in …

MaleTVPSettore MED/09 - Medicina InternaComorbidityLogistic regressionFondaparinuxVENOUS THROMBOEMBOLISM; THROMBOPROPHYLAXIS; Medical PatientsMedical patients; Thromboprophylaxis; Venous thromboembolism; Aged; Aged 80 and over; Area Under Curve; Comorbidity; Female; Hospital Mortality; Hospitalization; Humans; Logistic Models; Male; Propensity Score; Venous Thromboembolism; Internal Medicine; Emergency MedicineThromboprophylaxis Venous thromboembolism Medical patients80 and overHospital MortalityAged 80 and overSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheMedical patients; Thromboprophylaxis; Venous thromboembolism; Aged; Aged; 80 and over; Area Under Curve; Comorbidity; Female; Hospital Mortality; Hospitalization; Humans; Logistic Models; Male; Propensity Score; Venous Thromboembolism; Internal Medicine; Emergency Medicineprophylaxis; venous thromboembolism; elderlyHospitalizationArea Under CurveEmergency MedicineFemaleprophylaxismedicine.drugVenous thromboembolismmedicine.medical_specialtyThromboprophylaxis; Venous thromboembolismmultimorbidityBarthel indexvenous thromboembolismMEDLINEMedical patients; Thromboprophylaxis; Venous thromboembolism; Aged; Aged 80 and over; Area Under Curve; Comorbidity; Female; Hospital Mortality; Hospitalization; Humans; Logistic Models; Male; Propensity Score; Venous Thromboembolism; Emergency Medicine; Internal Medicineelderly patientselderlyMedical patientsInternal medicineInternal MedicinemedicineHumansMedical prescriptionprophylaxis; venous thromboembolism; elderly patientsPropensity ScoreIntensive care medicineThromboprophylaxisAgedbusiness.industryprophylaxiMedical patients; Thromboprophylaxis; Venous thromboembolismprophylaxis; Venous thromboembolism; Elderly; multimorbidity; medical patients; thromboprophylaxismedicine.diseaseComorbidityLogistic ModelsPropensity score matchingbusinessVenous thromboembolism
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Ceftolozane/Tazobactam for Treatment of Severe ESBL-Producing

2020

Abstract Background Few data are reported in the literature about the outcome of patients with severe extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections treated with ceftolozane/tazobactam (C/T), in empiric or definitive therapy. Methods A multicenter retrospective study was performed in Italy (June 2016–June 2019). Successful clinical outcome was defined as complete resolution of clinical signs/symptoms related to ESBL-E infection and lack of microbiological evidence of infection. The primary end point was to identify predictors of clinical failure of C/T therapy. Results C/T treatment was documented in 153 patients: pneumonia was the most common diagnosis (n = 46…

medicine.medical_specialtyceftolozane/tazobactammedicine.medical_treatmentCRRTTazobactamEnterobacteralesEnterobacteraleInternal medicineCRRT; ESBL; Enterobacterales; ceftolozane/tazobactam; septic shockMajor ArticlemedicineClinical endpointRenal replacement therapybusiness.industrySeptic shockRetrospective cohort studyOdds ratiomedicine.diseaseCeftolozane/tazobactam; CRRT; Enterobacterales; ESBL; Septic shockAcademicSubjects/MED00290Infectious DiseasesOncologyESBLseptic shockCeftolozanebusinessEmpiric therapymedicine.drugOpen forum infectious diseases
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Role of multidrug-resistant pathogens in health-care-associated pneumonia

2011

Comment on: Rethinking the concepts of community-acquired and health-care-associated pneumonia. [Lancet Infect Dis. 2010]

medicine.medical_specialtybusiness.industryHealth-care-associated pneumoniamedicine.diseaseHealth care associatedSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheNOMultidrug-resistant pathogensMultiple drug resistancePneumoniaInfectious Diseasesmedicinepneumonia multidrug-resistant pathogensHealth-care-associated pneumonia; Multidrug-resistant pathogensIntensive care medicinebusiness
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Clinical impact of broad-spectrum empirical antibiotic therapy in patients with healthcare-associated pneumonia: a multicenter interventional study

2012

Healthcare-associated pneumonia (HCAP) has been proposed as a new category of pneumonia distinct from community-acquired pneumonia (CAP). A multicenter observational study in 2008 finds that patients with HCAP have a mortality rate significantly higher than patients with CAP, and a worse outcome is associated at logistic regression analysis with a low adherence to empirical antibiotic therapy recommended by ATS/IDSA guidelines. We designed a prospective interventional study to establish whether administration of a broad-spectrum antibiotic therapy consistent with the 2005 ATS/IDSA guidelines has an effect on the clinical outcome of hospitalized patients with HCAP. All patients with HCAP pro…

AdultMalecommunity-acquired pneumonia; broad-spectrum empirical therapy; healthcare-associated pneumonia; multidrug-resistant pathogens; antibiotic therapymedicine.medical_specialtyCarbapenemcommunity-acquired pneumoniaSettore MED/09 - Medicina InternaAdolescentLogistic regressionNOYoung AdultCommunity-acquired pneumoniaDrug Resistance Multiple BacterialInternal medicinePneumonia BacterialInternal Medicinemedicineantibiotic therapyHumanspneumoniaProspective StudiesYoung adultIntensive care medicineProspective cohort studyAgedAged 80 and overCross Infectionbusiness.industryMortality ratehealthcare-associated pneumoniaHealthcare-associated pneumonia Community-acquired pneumonia Antibiotic therapy Multidrug-resistant pathogens Broad-spectrum empirical therapybroad-spectrum empirical therapyLength of StayMiddle Agedmedicine.diseaseSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheAnti-Bacterial AgentsPneumoniamultidrug-resistant pathogensItalyPractice Guidelines as TopicEmergency MedicineDrug Therapy CombinationFemaleObservational studybusinessantibiotic therapy; pneumoniamedicine.drug
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